ReviewAnnals of the New York Academy of Sciences2006
Pathogenesis of osteopenia/osteoporosis induced by highly active anti-retroviral therapy for AIDS.
Review in Annals of the New York Academy of Sciences, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 66 citations in OpenAlex.
- Early loss of bone mineral density is correlated with a gain of fat mass in patients starting a protease inhibitor containing regimen: the prospective Lipotrip study.BMC infectious diseases · 2013Trial
- Effect of reducing the dose of stavudine on body composition, bone density, and markers of mitochondrial toxicity in HIV-infected subjects: a randomized, controlled study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Trial
- Development and internal validation of a diagnostic prediction model for osteoporosis in elderly people living with HIV receiving antiretroviral therapy: a cross-sectional study.BMC infectious diseases · 2026Article
- Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026Review
- Case review of 3 patients with musculoskeletal manifestation of human immunodeficiency virus and highly active antiretroviral therapy in the form of osteopenia and insufficiency fractures.BJR case reports · 2026Review
- Femoral Neck Fractures in HIV-Positive Patients: Analysis of 10 Years Short-Term Post-operative Complications.Malaysian orthopaedic journal · 2021Article
- Retrospective study of the success of dental implants placed in HIV-positive patients.International journal of implant dentistry · 2019Article
- Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life.The Journal of clinical endocrinology and metabolism · 2017Article
- Management of endocrine disease: Secondary osteoporosis: pathophysiology and management.European journal of endocrinology · 2015Review
- HIV infection and osteoporosis.BoneKEy reports · 2015Review
- HIV and Bone Disease: A Perspective of the Role of microRNAs in Bone Biology upon HIV Infection.Journal of osteoporosis · 2013Review
- HIV and mitochondria: more than just drug toxicity.The Journal of infectious diseases · 2012Article
- Aging, human immunodeficiency virus, and bone health.Clinical interventions in aging · 2010Article
- Zidovudine and Lamivudine for HIV Infection.Clinical medicine reviews in therapeutics · 2010Article
- Is PPARγ a prospective player in HIV-1-associated bone disease?PPAR research · 2009Article
- Risk factors for decreased bone density and effects of HIV on bone in the elderly.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008Article
- HIV infection in the elderly.Clinical interventions in aging · 2008Review
- [Metabolic bone diseases].Der Internist · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The advent of highly active anti-retroviral therapy (HAART) has dramatically decreased the rate of AIDS-related mortality and significantly extended the life span of patients with AIDS. A variety of metabolic side effects are associated with these therapies, one of which is metabolic bone disease. A higher prevalence of osteopenia and osteoporosis in HIV-infected patients receiving anti-retroviral therapy than in patients not on therapy has now been reported in several studies. Several factors have been demonstrated to influence HIV-associated decreases in bone mineral density (BMD), including administration of nucleoside reverse transcriptase inhibitors (NRTIs). In this article, discussion will focus on the molecular pathogenesis and treatment of HAART-associated osteopenia and osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.