ArticlePlant molecular biology2006
Evolution of novel O-methyltransferases from the Vanilla planifolia caffeic acid O-methyltransferase.
Article in Plant molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Cell-Free Synthesis of Cannabistilbene I: A Dual Acting Anti-Inflammatory fromJournal of natural products · 2026Article
- Genetic Engineering Approaches for the Microbial Production of Vanillin.Biomolecules · 2024Review
- Evolution and diversification of the O-methyltransferase (OMT) gene family in Solanaceae.Genetics and molecular biology · 2023Article
- Article
- RNA-Seq and Iso-Seq Reveal the Important Role ofGenes · 2022Article
- Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-Plants (Basel, Switzerland) · 2022Review
- Genome-wide identification and characterization of COMT gene family during the development of blueberry fruit.BMC plant biology · 2021Article
- Article
- Molecular Cloning and Characterization of aInternational journal of molecular sciences · 2018Article
- A deep transcriptomic analysis of pod development in the vanilla orchid (Vanilla planifolia).BMC genomics · 2014Article
- Phylogenetic, Molecular, and Biochemical Characterization of Caffeic Acid o-Methyltransferase Gene Family in Brachypodium distachyon.International journal of plant genomics · 2013Article
- Functional characterization of two new members of the caffeoyl CoA O-methyltransferase-like gene family from Vanilla planifolia reveals a new class of plastid-localized O-methyltransferases.Plant molecular biology · 2011Article
- Two O-methyltransferases involved in the biosynthesis of methoxypyrazines: grape-derived aroma compounds important to wine flavour.Plant molecular biology · 2010Article
- Engineering monolignol 4-O-methyltransferases to modulate lignin biosynthesis.The Journal of biological chemistry · 2010Article
- Elucidation of the final reactions of DIMBOA-glucoside biosynthesis in maize: characterization of Bx6 and Bx7.Plant physiology · 2008Article
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Authors and funding
6 authors.
Funding
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Abstract
The biosynthesis of many plant secondary compounds involves the methylation of one or more hydroxyl groups, catalyzed by O-methyltransferases (OMTs). Here, we report the characterization of two OMTs, Van OMT-2 and Van OMT-3, from the orchid Vanilla planifolia Andrews. These enzymes catalyze the methylation of a single outer hydroxyl group in substrates possessing a 1,2,3-trihydroxybenzene moiety, such as methyl gallate and myricetin. This is a substrate requirement not previously reported for any OMTs. Based on sequence analysis these enzymes are most similar to caffeic acid O-methyltransferases (COMTs), but they have negligible activity with typical COMT substrates. Seven of 12 conserved substrate-binding residues in COMTs are altered in Van OMT-2 and Van OMT-3. Phylogenetic analysis of the sequences suggests that Van OMT-2 and Van OMT-3 evolved from the V. planifolia COMT. These V. planifolia OMTs are new instances of COMT-like enzymes with novel substrate preferences.
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