ArticleJournal of molecular evolution2006
Gene duplications and evolution of vertebrate voltage-gated sodium channels.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish.Science advances · 2022Article
- Article
- Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene.Molecular neurobiology · 2020Article
- Genomic discovery of ion channel genes in the central nervous system of the lamprey Petromyzon marinus.Marine genomics · 2019Article
- Comparative Transcriptome Analyses Reveal the Role of Conserved Function in Electric Organ Convergence Across Electric Fishes.Frontiers in genetics · 2019Article
- Brain activity patterns in high-throughput electrophysiology screen predict both drug efficacies and side effects.Nature communications · 2018Article
- Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene.Proceedings. Biological sciences · 2017Article
- Evidence for Non-neutral Evolution in a Sodium Channel Gene in African Weakly Electric Fish (Campylomormyrus, Mormyridae).Journal of molecular evolution · 2016Article
- Compensatory Drift and the Evolutionary Dynamics of Dosage-Sensitive Duplicate Genes.Genetics · 2016Article
- Target-Driven Evolution of Scorpion Toxins.Scientific reports · 2015Article
- Cross-tissue and cross-species analysis of gene expression in skeletal muscle and electric organ of African weakly-electric fish (Teleostei; Mormyridae).BMC genomics · 2015Article
- pigk Mutation underlies macho behavior and affects Rohon-Beard cell excitability.Journal of neurophysiology · 2015Article
- Article
- Evolutionary history of a complex adaptation: tetrodotoxin resistance in salamanders.Evolution; international journal of organic evolution · 2015Article
- Expression evolution facilitated the convergent neofunctionalization of a sodium channel gene.Molecular biology and evolution · 2014Article
- De novo assembly and characterization of tissue specific transcriptomes in the emerald notothen, Trematomus bernacchii.BMC genomics · 2013Article
- A naturally occurring amino acid substitution in the voltage-dependent sodium channel selectivity filter affects channel gating.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Adaptive evolution of voltage-gated sodium channels: the first 800 million years.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Multiple sodium channel variants in the mosquito Culex quinquefasciatus.International journal of biological sciences · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Voltage-gated sodium channels underlie action potential generation in excitable tissue. To establish the evolutionary mechanisms that shaped the vertebrate sodium channel alpha-subunit (SCNA) gene family and their encoded Nav1 proteins, we identified all SCNA genes in several teleost species. Molecular cloning revealed that teleosts have eight SCNA genes, compared to ten in another vertebrate lineage, mammals. Prior phylogenetic analyses have indicated that the genomes of both teleosts and tetrapods contain four monophyletic groups of SCNA genes, and that tandem duplications expanded the number of genes in two of the four mammalian groups. However, the number of genes in each group varies between teleosts and tetrapods, suggesting different evolutionary histories in the two vertebrate lineages. Our findings from phylogenetic analysis and chromosomal mapping of Danio rerio genes indicate that tandem duplications are an unlikely mechanism for generation of the extant teleost SCNA genes. Instead, analyses of other closely mapped genes in D. rerio as well as of SCNA genes from several teleost species all support the hypothesis that a whole-genome duplication was involved in expansion of the SCNA gene family in teleosts. Interestingly, despite their different evolutionary histories, mRNA analyses demonstrated a conservation of expression patterns for SCNA orthologues in teleosts and tetrapods, suggesting functional conservation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.