ArticleProceedings of the National Academy of Sciences of the United States of America2006
Minimal model of spiky oscillations in NF-kappaB signaling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 159 citations in OpenAlex.
- Autonomous Oscillations of NF-κB.Advances in experimental medicine and biology · 2026Review
- Analogue information processing in NF-κB gene regulatory system.Royal Society open science · 2025Article
- Article
- Entrainment and multi-stability of the p53 oscillator in human cells.Cell systems · 2024Article
- Predictive power of non-identifiable models.Scientific reports · 2023Article
- Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.NPJ systems biology and applications · 2023Article
- Article
- Spatiotemporal NF-κB dynamics encodes the position, amplitude, and duration of local immune inputs.Science advances · 2022Article
- NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuli.Cell reports · 2022Article
- Temperature Controls Onset and Period of NF-Frontiers in cell and developmental biology · 2022Article
- Diverse role of decoys on emergence and precision of oscillations in a biomolecular clock.Biophysical journal · 2021Article
- Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression.Cell death & disease · 2021Article
- Combinatorial dynamics of protein synthesis time delay and negative feedback loop in NF-IET systems biology · 2020Article
- Basal leakage in oscillation: Coupled transcriptional and translational control using feed-forward loops.PLoS computational biology · 2020Article
- On chaotic dynamics in transcription factors and the associated effects in differential gene regulation.Nature communications · 2019Article
- An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms.Frontiers in immunology · 2019Article
- Dissipative structures in biological systems: bistability, oscillations, spatial patterns and waves.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2018Review
- Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level.PLoS computational biology · 2018Article
- Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs).BMC systems biology · 2018Article
- Stochastic resonances in a distributed genetic broadcasting system: the NFJournal of the Royal Society, Interface · 2018Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NF-kappaB signaling system is involved in a variety of cellular processes including immune response, inflammation, and apoptosis. Recent experiments have found oscillations in the nuclear-cytoplasmic translocation of the NF-kappaB transcription factor [Hoffmann, A., et al. (2002) Science 298, ; Nelson, D. E., et al. (2004) Science 306, .] How the cell uses the oscillations to differentiate input conditions and send specific signals to downstream genes is an open problem. We shed light on this issue by examining the small core network driving the oscillations, which we show is designed to produce periodic spikes in nuclear NF-kappaB concentration. The presence of oscillations is extremely robust to variation of parameters, depending mainly on the saturation of the active degradation rate of IkappaB, an inhibitor of NF-kappaB. The oscillations can be used to regulate downstream genes in a variety of ways. In particular, we show that genes to whose operator sites NF-kappaB binds and dissociates fast can respond very sensitively to changes in the input signal, with effective Hill coefficients of >20.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.