ArticleBMJ (Clinical research ed.)2006
Whooping cough in school age children with persistent cough: prospective cohort study in primary care.
Article in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01279668 (A Double Blind Randomised Placebo Controlled Trial of Montelukast in the Treatment of Acute Persistent Cough in Young People and Adults in Primary Care), which is not on this map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Double Blind Randomised Placebo Controlled Trial of Montelukast in the Treatment of Acute Persistent Cough in Young People and Adults in Primary Care
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Coughing children in family practice and primary care: a systematic review of prevalence, aetiology and prognosis.BMC pediatrics · 2021Pooled it
- Guideline
- Prevalence of Atypical Pathogens in Patients With Cough and Community-Acquired Pneumonia: A Meta-Analysis.Annals of family medicine · 2016Pooled it
- Symptomatic treatment of the cough in whooping cough.The Cochrane database of systematic reviews · 2014Pooled it
- [Consensus statement on the evaluation and therapy of chronic cough in children].Wiener klinische Wochenschrift · 2014Guideline
- Review on pertussis case definitions: a need for reliable disease surveillance.BMC infectious diseases · 2026Review
- Epidemiological trends and pathogen analysis of pediatric acute respiratory infections in Hanzhong Hospital, China: insights from 2023 to 2024.Frontiers in public health · 2025Article
- Validating pertussis data measures using electronic medical record data in Ontario, Canada 1986-2016.Vaccine: X · 2023Article
- Prothrombotic, Proinflammatory Markers, and Troponin in Type 2 Diabetes Mellitus Might Be a Predictive Factors for Pulmonary Embolism.Materia socio-medica · 2023Article
- Epidemiological Insight of Pertussis in Bosnia and Herzegovina.Materia socio-medica · 2023Article
- Article
- Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2021Article
- Diagnosis and management of chronic cough: similarities and differences between children and adults.F1000Research · 2020Review
- Pertussis detection in children with cough of any duration.BMC pediatrics · 2019Article
- Pertussis and parapertussis in children and adults with a persistent cough: an observational study.Infection · 2018Observational
- Article
- Prevention of pertussis: An unresolved problem.Human vaccines & immunotherapeutics · 2018Review
- When is cough functional, and how should it be treated?Breathe (Sheffield, England) · 2017Review
- Persistent and Recurrent Bacterial Bronchitis-A Paradigm Shift in Our Understanding of Chronic Respiratory Disease.Frontiers in pediatrics · 2017Review
- Pertussis. A reemerging and an underreported infectious disease.Saudi medical journal · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTo estimate the proportion of school age children with a persistent cough who have evidence of a recent Bordetella pertussis infection.
designProspective cohort study (October 2001 to March 2005).
settingGeneral practices in Oxfordshire, England.
participants172 children aged 5-16 years who presented to their general practitioner with a cough lasting 14 days or more who consented to have a blood test.
main outcome measuresSerological evidence of a recent Bordetella pertussis infection; symptoms at presentation; duration and severity of cough; sleep disturbance (parents and child).
results64 (37.2%, 95% confidence interval 30.0% to 44.4%) children had serological evidence of a recent Bordetella pertussis infection; 55 (85.9%) of these children had been fully immunised. At presentation, children with whooping cough were more likely than others to have whooping (odds ratio 2.85, 95% confidence interval 1.39 to 5.82), vomiting (4.35, 2.04 to 9.25), and sputum production (2.39, 1.14 to 5.02). Children with whooping cough were also more likely to still be coughing two months after the start of their illness (85% v 48%; P = 0.001), continue to have more than five coughing episodes a day (P = 0.049), and cause sleep disturbance for their parents (P = 0.003).
conclusionsFor school age children presenting to primary care with a cough lasting two weeks or more, a diagnosis of whooping cough should be considered even if the child has been immunised. Making a secure diagnosis of whooping cough may prevent inappropriate investigations and treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.