ArticleIntensive care medicine2006
Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ESICM guidelines on circulatory shock and hemodynamic monitoring 2025.Intensive care medicine · 2025Guideline
- ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation.Intensive care medicine · 2008Trial
- Continuous monitoring of ScvO(2) by a new fibre-optic technology compared with blood gas oximetry in critically ill patients: a multicentre study.Intensive care medicine · 2007Trial
- Validation of the inadequate delivery of oxygen index in an adult cardiovascular intensive care unit.JTCVS open · 2024Article
- One approach to circulation and blood flow in the critical care unit.World journal of critical care medicine · 2019Review
- Oxygen Delivery and Oxygen Consumption in Pediatric Fluid Refractory Septic Shock During the First 42 h of Therapy and Their Relationship to 28-Day Outcome.Frontiers in pediatrics · 2018Article
- [Venous saturation : Between oxygen delivery and consumption].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2017Review
- Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock.World journal of critical care medicine · 2016Review
- Hemodynamic Monitoring in the Critically Ill Patient - Current Status and Perspective.Frontiers in medicine · 2015Review
- Central venous oxygenation: when physiology explains apparent discrepancies.Critical care (London, England) · 2014Review
- The multimodal concept of hemodynamic stabilization.Frontiers in public health · 2014Review
- Should We Monitor ScVO(2) in Critically Ill Patients?Cardiology research and practice · 2012Article
- Clinical review: use of venous oxygen saturations as a goal - a yet unfinished puzzle.Critical care (London, England) · 2011Review
- No agreement of mixed venous and central venous saturation in sepsis, independent of sepsis origin.Critical care (London, England) · 2010Article
- Tissue saturation measurement--exciting prospects, but standardisation and reference data still needed.Critical care (London, England) · 2010Article
- Association of physical examination with pulmonary artery catheter parameters in acute lung injury.Critical care medicine · 2009Article
- Central venous-to-arterial carbon dioxide difference: an additional target for goal-directed therapy in septic shock?Intensive care medicine · 2008Article
- Central venous to mixed venous blood oxygen and lactate gradients are associated with outcome in critically ill patients.Intensive care medicine · 2008Article
- The incidence of low venous oxygen saturation on admission to the intensive care unit: a multi-center observational study in The Netherlands.Critical care (London, England) · 2008Article
- Comment on Varpula et al.: Mixed venous oxygen saturation cannot be estimated by central venous oxygen saturation in septic shock.Intensive care medicine · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCentral venous oxygen saturation (ScvO2) in initial resuscitation is included in the Surviving Sepsis Campaign guidelines. ScvO2 monitoring has also been suggested to be comparable to mixed venous oxygen saturation (SvO2) for clinical purposes. The aim of our study was to assess the correlation and agreement of ScvO2 and SvO2 and compare ScvO2-SvO2 difference to lactate, oxygen-derived and hemodynamic parameters in early septic shock in ICU after initial resuscitation. DESIGN AND
settingProspective clinical study with 16 patients with septic shock at two university hospital ICUs. A dose of norepinephrine over 0.1 microg/kg/min was required for inclusion. MEASUREMENTS AND
resultsFive paired ScvO2 and SvO2 samples at 6-h intervals, altogether 72 samples, were collected during 24 h. The mean SvO2 was below the mean ScvO2 at all time points. Bias of difference was 4.2% and 95% limits of agreement ranged from -8.1% to 16.5%. The difference correlated significantly to CI and DO2.
conclusionsThe difference between paired ScvO2 and SvO2 varies highly. Therefore, SvO2 may not be estimated on the basis of ScvO2 in treatment of septic shock after resuscitation period in ICU.
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Registered trials
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