ArticleGenes and immunity2006
Transcriptional profiling of the peripheral blood response during tularemia.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Type I interferons in bacterial diseases: myeloid cells at the crossroads of protection and pathology.Frontiers in immunology · 2025Review
- Genome-wide host RNA signatures of infectious diseases: discovery and clinical translation.Immunology · 2018Review
- Vaccine-Mediated Mechanisms Controlling Replication ofFrontiers in cellular and infection microbiology · 2018Article
- Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood.Human vaccines & immunotherapeutics · 2017Article
- Tularemia vaccines.Folia microbiologica · 2016Review
- Article
- Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist.BMC genomics · 2015Article
- Expression profiling of lymph nodes in tuberculosis patients reveal inflammatory milieu at site of infection.Scientific reports · 2015Article
- ModuleBlast: identifying activated sub-networks within and across species.Nucleic acids research · 2015Article
- Article
- Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida.Journal of proteome research · 2012Article
- Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children.BMC infectious diseases · 2011Article
- Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.Microbes and infection · 2011Article
- Immunity to Francisella.Frontiers in microbiology · 2011Article
- Transcriptional response in the peripheral blood of patients infected with Salmonella enterica serovar Typhi.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Host immune response and acute disease in a zebrafish model of Francisella pathogenesis.Infection and immunity · 2009Article
- Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion.PloS one · 2008Article
- Transcriptional profiling of the peripheral blood response during tularemia.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tularemia is a febrile disease caused by the highly contagious bacterium Francisella tularensis. We undertook an analysis of the transcriptional response in peripheral blood during the course of ulceroglandular tularemia by use of Affymetrix microarrays comprising 14,500 genes. Samples were obtained from seven individuals at five occasions during 2 weeks after the first hospital visit and convalescent samples 3 months later. In total, 265 genes were differentially expressed, 95 of which at more than one time point. The differential expression was verified with real-time quantitative polymerase chain reaction for 36 genes (R(2)=0.590). The most prominent changes were noted in samples drawn on days 2-3 and a considerable proportion of the upregulated genes appeared to represent an interferon-gamma-induced response and also a proapoptotic response. Genes involved in the generation of innate and acquired immune responses were found to be downregulated, presumably a pathogen-induced event. A logistic regression analysis revealed that seven genes were good predictors of the early phase of tularemia. This is the first description of the transcriptional host response to ulceroglandular tularemia and the study has identified gene subsets relevant to the pathogenesis of the disease and subsets that may serve as early diagnostic biomarkers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.