ArticleGenome research2006
Genomic signatures of positive selection in humans and the limits of outlier approaches.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 1 of them a synthesis that pooled it.
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Who cites it
114 citing papers in PubMed, 1 synthesis or guideline pooled it, 219 citations in OpenAlex.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Towards an evolutionary baseline model ofbioRxiv : the preprint server for biology · 2025Article
- The persistence and loss of hard selective sweeps amid ancient human admixture.bioRxiv : the preprint server for biology · 2025Article
- A genomic tale of inbreeding in western Mediterranean human populations.Human genetics · 2025Article
- Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans.Genes · 2024Article
- Evolutionary genomics of socially polymorphic populations of Pogonomyrmex californicus.BMC biology · 2024Article
- Dissecting the genomic regions of selection on the X chromosome in different cattle breeds.3 Biotech · 2024Article
- Admixture has obscured signals of historical hard sweeps in humans.Nature ecology & evolution · 2022Article
- Ortholog genes from cactophilic Drosophila provide insight into human adaptation to hallucinogenic cacti.Scientific reports · 2022Article
- Demographic history differences between Hispanics and Brazilians imprint haplotype features.G3 (Bethesda, Md.) · 2022Article
- Green, yellow or black? Genetic differentiation and adaptation signatures in a highly migratory marine turtle.Proceedings. Biological sciences · 2021Article
- The population genetics of nonmigratory Allen's Hummingbird (Ecology and evolution · 2021Article
- Artificial selection causes significant linkage disequilibrium among multiple unlinked genes in Australian wheat.Evolutionary applications · 2019Article
- Patterns of genetic structure and adaptive positive selection in the Lithuanian population from high-density SNP data.Scientific reports · 2019Article
- Draft Genome Assembly and Population Genetics of an Agricultural Pollinator, the Solitary Alkali Bee (Halictidae:G3 (Bethesda, Md.) · 2019Article
- Localizing and Classifying Adaptive Targets with Trend Filtered Regression.Molecular biology and evolution · 2019Article
- PopHumanScan: the online catalog of human genome adaptation.Nucleic acids research · 2019Article
- Analysis of cross-population differentiation between Thoroughbred and Jeju horses.Asian-Australasian journal of animal sciences · 2018Article
54 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Identifying regions of the human genome that have been targets of positive selection will provide important insights into recent human evolutionary history and may facilitate the search for complex disease genes. However, the confounding effects of population demographic history and selection on patterns of genetic variation complicate inferences of selection when a small number of loci are studied. To this end, identifying outlier loci from empirical genome-wide distributions of genetic variation is a promising strategy to detect targets of selection. Here, we evaluate the power and efficiency of a simple outlier approach and describe a genome-wide scan for positive selection using a dense catalog of 1.58 million SNPs that were genotyped in three human populations. In total, we analyzed 14,589 genes, 385 of which possess patterns of genetic variation consistent with the hypothesis of positive selection. Furthermore, several extended genomic regions were found, spanning >500 kb, that contained multiple contiguous candidate selection genes. More generally, these data provide important practical insights into the limits of outlier approaches in genome-wide scans for selection, provide strong candidate selection genes to study in greater detail, and may have important implications for disease related research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.