ArticleJournal of medical genetics2006
New Alzheimer's disease locus on chromosome 8.
Article in Journal of medical genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mutation analysis of disease causing genes in patients with early onset or familial forms of Alzheimer's disease and frontotemporal dementia.BMC genomics · 2022Article
- Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia.Journal of Alzheimer's disease : JAD · 2010Review
- Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs.BMC medical genetics · 2009Article
- Endophenotypes in normal brain morphology and Alzheimer's disease: a review.Neuroscience · 2009Review
- Use of genetic variation as biomarkers for Alzheimer's disease.Annals of the New York Academy of Sciences · 2009Review
- Genetics of Alzheimer's disease: a centennial review.Neurologic clinics · 2007Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamily history is one of the most consistent risk factors for dementia. Therefore, analysis of families with a distinct inheritance pattern of disease can be a powerful approach for the identification of previously unknown disease genes.
objectiveTo map susceptibility regions for Alzheimer's disease.
methodsA complete genome scan with 369 microsatellite markers was carried out in 12 extended families collected in Sweden. Age at disease onset ranged from 53 to 78 years, but in 10 of the families there was at least one member with age at onset of < or =65 years. Mutations in known early-onset Alzheimer's disease susceptibility genes have been excluded. All people were genotyped for APOE, but no clear linkage with the epsilon4 allele was observed.
resultsAlthough no common disease locus could be found in all families, in two families an extended haplotype was identified on chromosome 8q shared by all affected members. In one of the families, a non-parametric multimarker logarithm of the odds (LOD) score of 4.2 (p = 0.004) was obtained and analysis based on a dominant model showed a parametric LOD score of 2.4 for this region. All six affected members of this family shared a haplotype of 10 markers spanning about 40 cM. Three affected members in another family also shared a haplotype in the same region.
conclusionOn the basis of our data, we propose the existence of a dominantly acting Alzheimer's disease susceptibility locus on chromosome 8.
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