ArticleJournal of clinical microbiology2006
Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed.
- Utilizing rapid multiple-locus variable-number tandem-repeat analysis typing to aid control of hospital-acquired Clostridium difficile Infection: a multicenter study.Journal of clinical microbiology · 2012Trial
- Ribotypes and New Virulent Strains Across Europe.Advances in experimental medicine and biology · 2024Review
- Update on Commonly Used Molecular Typing Methods forMicroorganisms · 2023Review
- Dogs as carriers of virulent and resistant genotypes of Clostridioides difficile.Zoonoses and public health · 2022Article
- Comparison of trends inThe Lancet regional health. Europe · 2022Article
- Genetic Relatedness of 5-Year Isolates ofAntibiotics (Basel, Switzerland) · 2021Article
- Biofilms harbour Clostridioides difficile, serving as a reservoir for recurrent infection.NPJ biofilms and microbiomes · 2021Article
- Multilocus Variable-Number Tandem-Repeat Analysis of Clostridioides difficile Clusters in Ribotype 027 Isolates and Lack of Association with Clinical Outcomes.Journal of clinical microbiology · 2019Article
- To Lump or To Split: Does Strain Lineage for Clostridioides difficile Matter?Journal of clinical microbiology · 2019Article
- Article
- Subtyping of Clostridium difficile PCR ribotypes 591, 106 and 002, the dominant strain types circulating in Medellin, Colombia.PloS one · 2018Article
- Molecular typing and antimicrobial susceptibility testing to six antimicrobials of Clostridium difficile isolates from three Czech hospitals in Eastern Bohemia in 2011-2012.Folia microbiologica · 2017Article
- Management of a cluster ofAntimicrobial resistance and infection control · 2017Article
- Characterisation of Clostridium difficile strains isolated from Groote Schuur Hospital, Cape Town, South Africa.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Development and evaluation of double locus sequence typing for molecular epidemiological investigations of Clostridium difficile.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Bacteriophage Combinations Significantly Reduce Clostridium difficile Growth In Vitro and Proliferation In Vivo.Antimicrobial agents and chemotherapy · 2016Article
- Molecular Epidemiology and Antimicrobial Susceptibility ofFrontiers in microbiology · 2016Article
- Clinical features and characteristics of Clostridium difficile PCR-ribotype 176 infection: results from a 1-year university hospital internal ward study.Annals of clinical microbiology and antimicrobials · 2015Article
- Evaluation of portability and cost of a fluorescent PCR ribotyping protocol for Clostridium difficile epidemiology.Journal of clinical microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Clostridium difficile is a major cause of antibiotic-associated gastrointestinal illness. Recently, an increased incidence of hospital-acquired infections with severe outcomes has been reported in North America and Europe. Current molecular-typing methods for detection of outbreaks and nosocomial transmission are labor-intensive, subjective, or insufficiently discriminatory to differentiate between closely related strains. This report describes the development of multilocus variable-number tandem-repeat (VNTR) analysis (MLVA) for molecular subtyping of C. difficile. Seven VNTR loci were identified from the C. difficile 630 genome by screening an isolate collection of various restriction endonuclease analysis (REA) types. The stability of the loci for short-term epidemiologic investigations was determined by performing MLVA on consecutive isolates of the same REA type from individual patients collected over as many as 90 days. Validation of MLVA for molecular genotyping was performed by direct comparison with REA results obtained from Hines Veterans Affairs Hospital on a combined collection of 40 C. difficile isolates from two different sources. The ability of MLVA to detect outbreaks was demonstrated on a collection of tertiary-care hospital isolates from a defined C. difficile outbreak in 2001. MLVA successfully clustered C. difficile isolates of the same REA type and discriminated isolates of unique REA type. Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission.
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