ArticleJournal of clinical microbiology2006
Illustration of a common framework for relating multiple typing methods by application to macrolide-resistant Streptococcus pyogenes.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
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182 citing papers in PubMed.
- A new core-genome MLST approach for Chlamydia trachomatis genomic surveillance and research.Nature communications · 2026Article
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- Fourier transform infrared spectroscopy reveals high intraspecies diversity ofbioRxiv : the preprint server for biology · 2026Article
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- Characterization of the CRISPR1-Cas array and its subtyping potential in Enterococcus faecalis from Malaysia.Access microbiology · 2026Article
- Fourier transform infrared spectroscopy enables rapid strain typing and cluster analysis ofFrontiers in microbiology · 2026Article
- Genetic Diversity of Methicillin-ResistantInternational journal of microbiology · 2026Article
- Evaluation of IR BIOTYPERAntimicrobial resistance and infection control · 2025Article
- Fourier transform infrared spectroscopy enables rapid species discrimination acrossbioRxiv : the preprint server for biology · 2025Article
- Development and validation of a core-genome multilocus sequence typing scheme forMicrobial genomics · 2025Article
- Multi-country and intersectoral assessment of cluster congruence between pipelines for genomics surveillance of foodborne pathogens.Nature communications · 2025Article
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- Comparative analysis of IR-Biotyper, MLST, cgMLST, and WGS for clustering of vancomycin-resistantMicrobiology spectrum · 2024Article
- Development and validation of a quick, automated, and reproducible ATR FT-IR spectroscopy machine-learning model forJournal of clinical microbiology · 2024Article
- Development of aFrontiers in microbiology · 2024Article
- Rapid typing ofFrontiers in microbiology · 2024Article
- Rapid Genotyping of Campylobacter coli Strains from Poultry Meat by PFGE, Sau-PCR, and fla-DGGE.Current microbiology · 2023Article
- ReporTree: a surveillance-oriented tool to strengthen the linkage between pathogen genetic clusters and epidemiological data.Genome medicine · 2023Article
- The emergence of carbapenemase-producingFrontiers in public health · 2023Article
- Genetic diversity and antimicrobial resistance profiles ofFrontiers in microbiology · 2023Article
122 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
The studies that correlate the results obtained by different typing methodologies rely solely on qualitative comparisons of the groups defined by each methodology. We propose a framework of measures for the quantitative assessment of correspondences between different typing methods as a first step to the global mapping of type equivalences. A collection of 325 macrolide-resistant Streptococcus pyogenes isolates associated with pharyngitis cases in Portugal was used to benchmark the proposed measures. All isolates were characterized by macrolide resistance phenotyping, T serotyping, emm sequence typing, and pulsed-field gel electrophoresis (PFGE), using SmaI or Cfr9I and SfiI. A subset of 41 isolates, representing each PFGE cluster, was also characterized by multilocus sequence typing (MLST). The application of Adjusted Rand and Wallace indices allowed the evaluation of the strength and the directionality of the correspondences between the various typing methods and showed that if PFGE or MLST data are available one can confidently predict the emm type (Wallace coefficients of 0.952 for both methods). In contrast, emm typing was a poor predictor of PFGE cluster or MLST sequence type (Wallace coefficients of 0.803 and 0.655, respectively). This was confirmed by the analysis of the larger data set available from http://spyogenes.mlst.net and underscores the necessity of performing PFGE or MLST to unambiguously define clones in S. pyogenes.
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