ArticleJournal of clinical microbiology2006
Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Pooled it
- Estimating the incidence of symptomatic rotavirus infections: a systematic review and meta-analysis.PloS one · 2009Pooled it
- Pediatric Rotavirus A Infection Among 337,019 Participants Within Asia: A Pan-Asian Systematic Review and Meta-Analysis.Journal of tropical medicine · 2026Review
- Epidemiology and Clinical Profile of Rotavirus Diarrhea in Children Aged Under 5 Years in Kerala, India After the Introduction of Rotavirus Vaccination: A Surveillance Study.Indian journal of pediatrics · 2025Observational
- Factors Associated with Rotavirus Positivity in Children with Acute Gastroenteritis in Jharkhand, India (2019-2023).Indian journal of pediatrics · 2025Article
- Transforming Global Health: Dr. Gagandeep Kang's Legacy in Microbiology and Public Health.Cureus · 2024Review
- Rotavirus Diarrhea and its Determinants Among Under-Five Children Admitted in a Tertiary Care Hospital of Southern Haryana, India.Indian journal of pediatrics · 2021Observational
- Acute Gastroenteritis in Children Below 5 Years of Age at Tirupati, Andhra Pradesh, India Post Introduction of Rotavirus Vaccine into National Immunization Programme.Indian journal of pediatrics · 2021Article
- Diversity of Rotavirus Strains in Children; Results From a Community-Based Study in Nepal.Frontiers in medicine · 2021Article
- The Burden of Rotavirus Gastroenteritis in Children: A Hospital-Based Prospective Study in Western Rajasthan.Cureus · 2020Article
- Article
- Estimated impact of rotavirus vaccine on hospitalizations and deaths from rotavirus diarrhea among children <5 in Asia.Expert review of vaccines · 2018Article
- Health impact and cost-effectiveness of a domestically-produced rotavirus vaccine in India: A model based analysis.PloS one · 2017Article
- Molecular Characterization of Human Rotavirus from Children with Diarrhoeal Disease in Sokoto State, Nigeria.Molecular biology international · 2016Article
- Clinical Symptoms of Human Rotavirus Infection Observed in Children in Sokoto, Nigeria.Advances in virology · 2015Article
- Diagnosis of viral gastroenteritis in children: interpretation of real-time PCR results and relation to clinical symptoms.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Factors associated with diarrhoea in young children and incidence of symptomatic rotavirus infection in rural West Bengal, India.Epidemiology and infection · 2014Article
- Prevalence of rotavirus infection in children below two years presenting with diarrhea.Medical journal, Armed Forces India · 2014Article
- Cost-effectiveness of a new rotavirus vaccination program in Pakistan: a decision tree model.Vaccine · 2013Article
- Epidemiology and clinical features of rotavirus and norovirus infection among children in Ji'nan, China.Virology journal · 2013Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Rotavirus gastroenteritis is the major cause of severe dehydrating diarrhea in children worldwide. This study compares rotavirus diarrhea in 351 children in a community-based cohort and 343 children admitted to a hospital during the same period. Clinical information and fecal specimens were obtained during diarrheal episodes. Fecal samples were screened for VP6 antigen, and the positive samples were G and P typed by reverse transcription-PCR. Rotavirus was detected in 82/1,152 (7.1%) episodes of diarrhea in the community and 94/343 (27.4%) cases in the hospital. The median age of affected children (7.5 versus 10.5 months) and the mean severity of symptoms (Vesikari score, 7.6+/-3.4 versus 11+/-2.5) were lower in the community. A larger proportion of children in the community were breast-fed than were children admitted to the hospital (73% versus 34.8%). In the community, the genotypes identified in symptomatic patients, in order of frequency, were G1 (36.5%), G10 (17.1%), G2 (15.9%), and G9 (7.3%) and mixed infections (7.3%). The most common G-P combinations were G1P[8], G2P[4], G1P[4], and G10P[11]. The distribution of G types from hospitalized children was G1 (46.8%), G9 (19.1%), G2 (8.5%), G10 (1.1%), and 4.3% mixed infections. The most common G-P combinations were G1P[8] and G9P[8]. This study documents significant genetic heterogeneity of rotaviruses in the community and the hospital. G10P[11] strains resembling a vaccine candidate strain caused disease in the community, indicating the need for careful epidemiological studies as well as safety studies for the vaccine candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.