ArticleThe Journal of physiology2006
Prenatal exposure to interleukin-6 results in hypertension and alterations in the renin-angiotensin system of the rat.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Tocilizumab, An Interleukin-6 Receptor Antibody, For Residual Symptoms in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Targeting the P2X7 receptor signaling pathway: Unlocking therapeutic strategies for autism spectrum disorder.Brain, behavior, & immunity - health · 2025Review
- Inflammatory Biomarkers in Hypertension.Current medicinal chemistry · 2025Review
- A new immune disease: systemic hypertension.Clinical kidney journal · 2023Review
- Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature.International journal of molecular sciences · 2023Review
- Maternal Inflammation Exaggerates Offspring Susceptibility to Cerebral Ischemia-Reperfusion Injury via the COX-2/PGD2/DPOxidative medicine and cellular longevity · 2022Article
- Transplanted senescent renal scattered tubular-like cells induce injury in the mouse kidney.American journal of physiology. Renal physiology · 2020Article
- Arterial Hypertension and Interleukins: Potential Therapeutic Target or Future Diagnostic Marker?International journal of hypertension · 2019Review
- DNA Methylation and Histone Modification in Hypertension.International journal of molecular sciences · 2018Review
- Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis.Frontiers in endocrinology · 2018Review
- Ascorbic Acid Protects against Hypertension through Downregulation of ACE1 Gene Expression Mediated by Histone Deacetylation in Prenatal Inflammation-Induced Offspring.Scientific reports · 2016Article
- Diet, behavior and immunity across the lifespan.Neuroscience and biobehavioral reviews · 2015Review
- Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.Alzheimer's research & therapy · 2015Article
- Fetal programming and cardiovascular pathology.Comprehensive Physiology · 2015Review
- The cytokine model of schizophrenia: emerging therapeutic strategies.Biological psychiatry · 2014Review
- Prenatal influenza exposure and cardiovascular events in adulthood.Influenza and other respiratory viruses · 2014Article
- Prenatal exposure to lipopolysaccharide results in myocardial remodelling in adult murine offspring.Journal of inflammation (London, England) · 2013Article
- Ontogeny of angiotensin type 2 and type 1 receptor expression in mice.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2012Article
- Dopamine and renal function and blood pressure regulation.Comprehensive Physiology · 2011Review
- Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokines are emerging as important in developmental processes. They may induce alterations in normal gene expression patterns, activate angiotensinogen transcription, or alter expression of the renin-angiotensin system (RAS). To determine whether prenatal exposure to interleukin-6 (IL-6) influences gene expression of the intrarenal RAS and contributes to renal dysfunction and hypertension in adulthood, we exposed female rats to IL-6 early (EIL-6 females) and late (LIL-6 females) in pregnancy and analysed blood pressure in the offspring at 5-20 weeks of age. Renal fluid and electrolyte excretion was assessed in clearance experiments, mRNA expression by real-time PCR, and protein levels by Western blot. Systolic pressure was increased at 5 weeks in IL-6 females and at 11 weeks in males. Circulatory RAS levels were increased in all IL-6 females, but angiotensin-1-converting enzyme (ACE) activity was increased only in LIL-6 females. LIL-6 males and IL-6 females showed decreased urinary flow rate and urinary sodium and potassium excretion. Dopamine excretion was decreased IL-6 females. In adult renal cortex, renin expression was increased in all IL-6 females, but angiotensinogen mRNA was increased only in LIL-6 females; AT(1) receptor (AT(1)-R) mRNA and protein levels were increased in LIL-6 females, whereas AT(2) receptor (AT(2)-R) levels were decreased in LIL-6 females and EIL-6 males. In adult renal medulla, AT(1)-R protein levels were increased in LIL-6 females, and AT(2)-R mRNA and protein levels were decreased in EIL-6 males and LIL-6 females. Prenatal IL-6 exposure may cause hypertension by altering the renal and circulatory RAS and renal fluid and electrolyte excretion, especially in females.
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Registered trials
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