ArticleThe Journal of physiology2006
Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Advanced progress of vestibular compensation in vestibular neural networks.CNS neuroscience & therapeutics · 2024Review
- Histaminergic System and Vestibular Function in Normal and Pathological Conditions.Current neuropharmacology · 2024Review
- Article
- How Does the Central Nervous System for Posture and Locomotion Cope With Damage-Induced Neural Asymmetry?Frontiers in systems neuroscience · 2022Review
- Reduced Balance Restoration Capacities Following Unilateral Vestibular Insult in Elderly Mice.Frontiers in neurology · 2018Article
- MicroRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation.Scientific reports · 2017Article
- Vestibular compensation: the neuro-otologist's best friend.Journal of neurology · 2016Review
- Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat.Frontiers in integrative neuroscience · 2014Article
- The changes in mGluR2 and mGluR7 expression in rat medial vestibular nucleus and flocculus following unilateral labyrinthectomy.International journal of molecular sciences · 2013Article
- Article
- Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice.Neuroscience · 2010Article
- Advances in Auditory and Vestibular Medicine.Audiological medicine · 2009Article
- Auditory proteomics: methods, accomplishments and challenges.Brain research · 2009Review
- Asymmetric recovery in cerebellar-deficient mice following unilateral labyrinthectomy.Journal of neurophysiology · 2008Article
- Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene.Molecular & cellular proteomics : MCP · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The molecular mechanisms of neural and synaptic plasticity in the vestibular nuclei during 'vestibular compensation', the behavioural recovery that follows deafferentation of one inner ear, are largely unknown. In this study we have used differential proteomics techniques to determine changes in protein expression in ipsi-lesional and contra-lesional medial vestibular nuclei (MVN) of rats, 1 week after either sham surgery or unilateral labyrinthectomy (UL). A systematic comparison of 634 protein spots in two-dimensional electrophoresis gels across five experimental conditions revealed 54 spots, containing 26 proteins whose level was significantly altered 1 week post-UL. The axon-guidance-associated proteins neuropilin-2 and dehydropyriminidase-related protein-2 were upregulated in the MVN after UL. Changes in levels of further specific proteins indicate a coordinated upregulation of mitochondrial function, ATP biosynthesis and phosphate metabolism in the vestibular nuclei 1 week post-UL. These may reflect the metabolic energy demands of processes such as gliosis, neuronal outgrowth and synaptic remodelling that occur after UL. Our findings suggest novel roles for axon elaboration and guidance molecules, as well as mitochondrial and metabolic regulatory proteins, in the post-lesional physiology of the MVN during vestibular system plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.