ArticleJournal of virology1991
The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 75 citations in OpenAlex.
- Unveiling the role of hexon-associated host proteins in fowl adenovirus serotype 4 replication.Frontiers in veterinary science · 2025Article
- Article
- p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation.Molecular and cellular biology · 1999Article
- Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A-associated protein p107.Journal of virology · 1998Article
- Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression.Molecular and cellular biology · 1997Article
- Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3.Molecular and cellular biology · 1997Article
- Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter.Journal of virology · 1997Article
- The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif.Molecular and cellular biology · 1996Article
- YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity.Molecular and cellular biology · 1996Article
- Domains A and B in the Rb pocket interact to form a transcriptional repressor motif.Molecular and cellular biology · 1996Article
- The CR1 and CR3 domains of the adenovirus type 5 E1A proteins can independently mediate activation of ATF-2.Journal of virology · 1996Article
- CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors.The EMBO journal · 1996Article
- Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Transcription factors RFX1/EF-C and ATF-1 associate with the adenovirus E1A-responsive element of the human proliferating cell nuclear antigen promoter.Nucleic acids research · 1995Article
- Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.Molecular and cellular biology · 1994Article
- Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.Molecular and cellular biology · 1994Article
- Modulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activators.Molecular and cellular biology · 1994Article
- Repression of RNA polymerase III transcription by adenovirus E1A.Journal of virology · 1993Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The transforming region of adenovirus (E1) stimulates expression of a reporter construct linked to the promoter for the human proliferating cell nuclear antigen (PCNA) gene in a cotransfection assay (G. F. Morris and M. B. Mathews, J. Biol. Chem. 264:13856-13864, 1989). The major products of the E1 region were assessed individually for their contribution to transactivation of the PCNA promoter. The E1A 13S and 12S products and the E1B 19-kDa product elevated expression from the PCNA promoter, whereas the E1B 55-kDa product did not. Induction of the PCNA promoter by E1A differed from transcriptional activation of the adenovirus E3 promoter in that the PCNA promoter is activated by the E1A 12S product whereas the E3 promoter is repressed; furthermore, the PCNA promoter is activated upon E1A overexpression, whereas the E3 promoter responds less well to high amounts of E1A. A site for the activating transcription factor ATF located approximately 50 nucleotides upstream from the transcription initiation site in the PCNA promoter mediates a positive response to the E1A 12S and 13S products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.