ArticleThe Journal of biological chemistry2006
Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism.
Article in The Journal of biological chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.International journal of molecular sciences · 2022Article
- Calcium-Dependent Ion Channels and the Regulation of Arteriolar Myogenic Tone.Frontiers in physiology · 2021Review
- Review
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel.Handbook of experimental pharmacology · 2014Review
- Activation and regulation of store-operated calcium entry.Journal of cellular and molecular medicine · 2010Review
- Ins(1,4,5)P3 interacts with PIP2 to regulate activation of TRPC6/C7 channels by diacylglycerol in native vascular myocytes.The Journal of physiology · 2010Article
- TRPC channels function independently of STIM1 and Orai1.The Journal of physiology · 2009Article
- Roles of TRP channels in the development of cardiac hypertrophy.Naunyn-Schmiedeberg's archives of pharmacology · 2008Review
- Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate.Cell calcium · 2008Article
- Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells.British journal of pharmacology · 2007Article
- TRPC channels as STIM1-regulated store-operated channels.Cell calcium · 2007Review
- STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels.Nature cell biology · 2007Article
- Endothelin-1 activates a Ca2+-permeable cation channel with TRPC3 and TRPC7 properties in rabbit coronary artery myocytes.The Journal of physiology · 2007Article
- TRP channels.Annual review of biochemistry · 2007Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In DT40 B lymphocytes, Canonical Transient Receptor Potential 7 (TRPC7) functions as a diacylglycerol-activated non-selective cation channel. However, previous work indicated that the non-store-operated Ca2+ entry in this cell type depends upon inositol trisphosphate receptors (IP3R). With the cell-attached configuration oleyl-acetyl-glycerol (OAG) induced single channel activity (75 pS) that was not observed in TRPC7-/- cells but was rescued by expression of TRPC7 under conditions expected to produce relatively low levels of expression ((LowT7)TRPC7-/-). A DT40 cell line lacking IP3R(IP3R-/- cells) showed no OAG-induced single channel activity, but this activity was rescued by transient expression of an IP3R((IP3R)IP3R-/-). Single channel properties in (LowT7)TRPC7-/- or (IP3R)IP3R-/- DT40 cells were indistinguishable from one another and from wild-type cells. Thus, TRPC7 forms, or is part of, the channel underlying endogenous diacylglycerol-activated currents in DT40 B lymphocytes, and this activity of native TRPC7 requires IP3R. However, with conditions expected to produce greater expression levels, TRPC7 functioned independently of the presence of IP3R. This finding may serve to resolve previously conflicting reports from expression studies of TRPC channels.
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