ArticleMolecular biology of the cell2006
Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- The role of actin cytoskeleton component Arp2/3 in inflammatory response.Frontiers in cell and developmental biology · 2025Review
- The actin cytoskeleton plays multiple roles in structural colour formation in butterfly wing scales.Nature communications · 2024Article
- Actin-related protein 2/3 complex subunit 2-enriched extracellular vesicles drive liver cancer metastasis.Hepatology international · 2022Article
- Isoform-specific roles of the Drosophila filamin-type protein Jitterbug (Jbug) during development.Genetics · 2021Article
- Profilin and Mical combine to impair F-actin assembly and promote disassembly and remodeling.Nature communications · 2021Article
- Propagation of F-actin disassembly via Myosin15-Mical interactions.Science advances · 2021Article
- ARPC2 promotes breast cancer proliferation and metastasis.Oncology reports · 2019Article
- IKKε inhibits PKC to promote Fascin-dependent actin bundling.Development (Cambridge, England) · 2016Article
- Cofilin-mediated actin dynamics promotes actin bundle formation during Drosophila bristle development.Molecular biology of the cell · 2016Article
- Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.PloS one · 2014Article
- The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle.Molecular and cellular biology · 2011Article
- Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle.Molecular and cellular biology · 2010Article
- Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.Developmental biology · 2009Article
- Protein localization by actin treadmilling and molecular motors regulates stereocilia shape and treadmilling rate.Biophysical journal · 2008Article
- The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning.The Journal of cell biology · 2008Article
- New insights into mechanism and regulation of actin capping protein.International review of cell and molecular biology · 2008Review
- The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells.Genetics · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila melanogaster bristle development is dependent on actin assembly, and prominent actin bundles form against the elongating cell membrane, giving the adult bristle its characteristic grooved pattern. Previous work has demonstrated that several actin-regulating proteins are required to generate normal actin bundles. Here we have addressed how two actin regulators, capping protein, a barbed end binding protein, and the Arp2/3 complex, a potent actin assembly nucleator, function to generate properly organized bundles. As predicted from studies in motile cells, we find that capping protein and the Arp2/3 complex act antagonistically to one another during bristle development. However, these proteins do not primarily act directly on bundles, but rather on a dynamic population of actin filaments that are not part of the bundles. These nonbundle filaments, termed snarls, play an important role in determining the number and spacing of the actin bundles. Reduction of capping protein leads to an increase in snarls, which prevents actin bundles from properly attaching to the membrane. Conversely, loss of an Arp2/3 complex component leads to a loss of snarls and accumulation of excess membrane-attached bundles. These results indicate that in nonmotile cells dynamic actin filaments can function to regulate the positioning of stable actin structures. In addition, our results suggest that the Arpc1 subunit may have an additional function, independent of the rest of the Arp2/3 complex.
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