Evidence map›Paper›PMID 16822380›Full record

ReviewCurrent allergy and asthma reports2006

Urticaria pigmentosa and mastocytosis: the role of immunophenotyping in diagnosis and determining response to treatment.

Cem Akin, Peter Valent, Luis Escribano

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Primary mast cell disorders in children.Current allergy and asthma reports · 2013
    Review
  3. Review
  4. Article
  5. Article
  6. Mastocytosis: advances in diagnosis and treatment.Current allergy and asthma reports · 2007
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cem AkinDepartment of Internal Medicine, University of Michigan, 4220-D MSRB-3, Box 0638, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0638, USA. cemakin@umich.edu
Peter Valent
Luis Escribano

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in our understanding of mast cell biology and disease resulted in identification of important differences in expression of mast cell surface antigens in normal and neoplastic mast cells. Most notably, detection of aberrant expression of CD25 and CD2 on the surface of neoplastic mast cells but not on their normal counterparts leads to the inclusion of this immunophenotypic abnormality in the World Health Organization's diagnostic criteria for systemic mastocytosis. Aberrant mast cell surface marker expression can be detected in the bone marrow aspirate by flow cytometry, even in patients with limited disease that lacks histopathologically detectable aggregates of mast cells in bone marrow biopsy sections. Flow cytometric analysis of bone marrow mast cells is therefore a sensitive method of diagnosis of mast cell disease and is expected to find increasing use in determining response to emerging mast cell cytoreductive therapies.

Indexed as

Biomarkers, TumorBiopsyBone MarrowCD2 AntigensDiagnosis, DifferentialGene Expression Regulation, NeoplasticImmunophenotypingMast CellsMastocytosis, SystemicSialic Acid Binding Ig-like Lectin 2Urticaria PigmentosaBiomarkers, TumorCD2 AntigensSialic Acid Binding Ig-like Lectin 2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.