ArticleLipids in health and disease2006
The lipoprotein lipase gene in combined hyperlipidemia: evidence of a protective allele depletion.
Article in Lipids in health and disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- DNA polymorphisms of the lipoprotein lipase gene and their association with coronary artery disease in the Saudi population.International journal of molecular sciences · 2012Trial
- Glycyrrhizic Acid and Its Derivatives: Promising Candidates for the Management of Type 2 Diabetes Mellitus and Its Complications.International journal of molecular sciences · 2022Review
- Association of Metabolic Syndrome with Aerobic Exercise and LPL rs3779788 Polymorphism in Taiwan Biobank Individuals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids.Journal of lipid research · 2020Article
- The Association of Lipoprotein Lipase Genes, HindIII and S447X Polymorphisms With Coronary Artery Disease in Shiraz City.Journal of cardiovascular and thoracic research · 2015Article
- Lipoprotein lipase gene Hind III polymorphism was associated with hemorrhagic stroke.International journal of clinical and experimental medicine · 2015Article
- Association between Expression Quantitative Trait Loci and Metabolic Traits in Two Korean Populations.PloS one · 2014Article
- Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease.Biomedical reports · 2013Article
- Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia.Lipids in health and disease · 2009Article
- New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia.Journal of lipid research · 2009Review
- Galanin preproprotein is associated with elevated plasma triglycerides.Arteriosclerosis, thrombosis, and vascular biology · 2009Article
- The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.Diabetologia · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLipoprotein Lipase (LPL), a key enzyme in lipid metabolism, catalyzes the hydrolysis of triglycerides (TG) from TG-rich lipoproteins, and serves a bridging function that enhances the cellular uptake of lipoproteins. Abnormalities in LPL function are associated with pathophysiological conditions, including familial combined hyperlipidemia (FCH). Whereas two LPL susceptibility alleles were found to co-segregate in a few FCH kindred, a role for common, protective alleles remains unexplored. The LPL Ser447Stop (S447X) allele is associated with anti-atherogenic lipid profiles and a modest reduction in risk for coronary disease. We hypothesize that significant depletion of the 447X allele exists in combined hyperlipidemia cases versus controls. A case-control design was employed. The polymorphism was assessed by restriction assay in 212 cases and 161 controls. Genotypic, allelic, and phenotypic associations were examined.
resultsWe found evidence of significant allelic (447Xcontrol: 0.130 vs. 447Xcase: 0.031, chi2 = 29.085; 1df; p < 0.001) and genotypic association (SS: 0.745 vs. 0.939, and SX+XX: 0.255 vs. 0.061) in controls and cases, respectively (chi2 = 26.09; 1df; p < 0.001). In cases, depletion of the 447X allele is associated with a significant elevation in very-low-density lipoprotein cholesterol (VLDL-C, p = 0.045). Consonant with previous studies of this polymorphism, regression models predict that carriers of the 447X allele displayed significantly lower TG, low-density lipoprotein cholesterol (LDL-C) and TG/high-density lipoprotein cholesterol (HDL-C) ratio.
conclusionThese findings suggest a role for the S447X polymorphism in combined hyperlipidemia and demonstrate the importance of evaluating both susceptibility and protective genetic risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.