ArticleApplied and environmental microbiology2006
Effects of low-shear modeled microgravity on cell function, gene expression, and phenotype in Saccharomyces cerevisiae.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 99 citations in OpenAlex.
- Yeast-driven biomanufacturing in space: synergizing cellular agriculture for sustainable extraterrestrial habitats.NPJ microgravity · 2026Review
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Extremophiles in Space Exploration.Indian journal of microbiology · 2024Review
- Biofilm reactors for the treatment of used water in space:potential, challenges, and future perspectives.Biofilm · 2023Article
- How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond.Frontiers in microbiology · 2023Review
- Differentiation of human induced pluripotent stem cells into functional lung alveolar epithelial cells in 3D dynamic culture.Frontiers in bioengineering and biotechnology · 2023Article
- Simulated Microgravity Created Using a Random Positioning Machine Induces Changes in the Physiology of theMicroorganisms · 2022Article
- Harnessing bioengineered microbes as a versatile platform for space nutrition.Nature communications · 2022Review
- An Electro-Microbial Process to Uncouple Food Production from Photosynthesis for Application in Space Exploration.Life (Basel, Switzerland) · 2022Article
- The International Space Station Environment Triggers Molecular Responses inFrontiers in microbiology · 2022Article
- Article
- Advances in space microbiology.iScience · 2021Review
- Spaceflight and simulated microgravity conditions increase virulence ofNPJ microgravity · 2020Article
- Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism.Military Medical Research · 2018Review
- Transcriptional profiling of the mutualistic bacteriumNPJ microgravity · 2018Article
- The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism.Progress in biophysics and molecular biology · 2017Review
- Response of extreme haloarchaeon Haloarcula argentinensis RR10 to simulated microgravity in clinorotation.3 Biotech · 2017Article
- Phenotypic Changes Exhibited byFrontiers in microbiology · 2017Article
- Article
- Biologic relativity: Who is the observer and what is observed?Progress in biophysics and molecular biology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Only limited information is available concerning the effects of low-shear modeled microgravity (LSMMG) on cell function and morphology. We examined the behavior of Saccharomyces cerevisiae grown in a high-aspect-ratio vessel, which simulates the low-shear and microgravity conditions encountered in spaceflight. With the exception of a shortened lag phase (90 min less than controls; P < 0.05), yeast cells grown under LSMMG conditions did not differ in growth rate, size, shape, or viability from the controls but did differ in the establishment of polarity as exhibited by aberrant (random) budding compared to the usual bipolar pattern of controls. The aberrant budding was accompanied by an increased tendency of cells to clump, as indicated by aggregates containing five or more cells. We also found significant changes (greater than or equal to twofold) in the expression of genes associated with the establishment of polarity (BUD5), bipolar budding (RAX1, RAX2, and BUD25), and cell separation (DSE1, DSE2, and EGT2). Thus, low-shear environments may significantly alter yeast gene expression and phenotype as well as evolutionary conserved cellular functions such as polarization. The results provide a paradigm for understanding polarity-dependent cell responses to microgravity ranging from pathogenesis in fungi to the immune response in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.