ArticleNeoplasia (New York, N.Y.)2006
Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement.
Article in Neoplasia (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of SPINK1 in ETS rearrangement-negative prostate cancers.Cancer cell · 2008Pooled it
- Uncovering the role of ETS2 in prostate cancer pathogenesis: relationship with p53 and ERG.Molecular biology reports · 2026Article
- Oncogenic Fusions HarboringCancers · 2025Review
- Genomic and Immunologic Correlates in Prostate Cancer with High Expression of KLK2.International journal of molecular sciences · 2024Article
- The potential role of the microbiota in prostate cancer pathogenesis and treatment.Nature reviews. Urology · 2023Review
- The evolving landscape of prostate cancer somatic mutations.The Prostate · 2022Review
- Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature.Frontiers in cell and developmental biology · 2021Article
- The Genetic Complexity of Prostate Cancer.Genes · 2020Review
- Loss of Notch1 Activity Inhibits Prostate Cancer Growth and Metastasis and Sensitizes Prostate Cancer Cells to Antiandrogen Therapies.Molecular cancer therapeutics · 2019Article
- The Genomics of Prostate Cancer: A Historic Perspective.Cold Spring Harbor perspectives in medicine · 2019Review
- Preparation of fluorescent in situ hybridisation probes without the need for optimisation of fragmentation.MethodsX · 2019Article
- Gene Fusion in Malignant Glioma: An Emerging Target for Next-Generation Personalized Treatment.Translational oncology · 2018Review
- Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections.Laboratory investigation; a journal of technical methods and pathology · 2018Review
- Association between TMPRSS2:ERG fusion gene and the prostate cancer: systematic review and meta-analysis.Central European journal of urology · 2018Review
- Molecular alterations in prostate cancer and association with MRI features.Prostate cancer and prostatic diseases · 2017Article
- FluorescenceThe journal of pathology. Clinical research · 2017Review
- Chimeric Genes in Deletions and Duplications Associated with Intellectual Disability.International journal of genomics · 2017Article
- CRISPR-Induced TMPRSS2-ERG Gene Fusions in Mouse Prostate Organoids.JSM biotechnology & biomedical engineering · 2017Article
- A simple, rapid, low-cost technique for naked-eye detection of urine-isolated TMPRSS2:ERG gene fusion RNA.Scientific reports · 2016Article
- Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer.Oncology letters · 2016Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent description of novel recurrent gene fusions in approximately 80% of prostate cancer (PCa) cases has generated increased interest in the search for new translocations in other epithelial cancers and emphasizes the importance of understanding the origins and biologic implications of these genomic rearrangements. Analysis of 15 PCa cases by reverse transcription-polymerase chain reaction was used to detect six ERG-related gene fusion transcripts with TMPRSS2. No TMPRSS2/ETV1 chimeric fusion was detected in this series. Three-color fluorescence in situ hybridization confirms that TMPRSS2/ERG fusion may be accompanied by a small hemizygous sequence deletion on chromosome 21 between ERG and TMPRSS2 genes. Analysis of genomic architecture in the region of genomic rearrangement suggests that tracts of microhomology could facilitate TMPRSS2/ERG fusion events.
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