ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2006
Bacterial coinfections in children with viral wheezing.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Clinical symptoms and signs for the diagnosis of Mycoplasma pneumoniae in children and adolescents with community-acquired pneumonia.The Cochrane database of systematic reviews · 2012Pooled it
- Pooled it
- Atopic characteristics of wheezing children and responses to prednisolone.Pediatric pulmonology · 2007Trial
- Impact of the COVID-19 Pandemic on Epidemiological Trends in Pediatric Cervical Abscess-Forming Infections.Microorganisms · 2025Article
- Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis.Frontiers in immunology · 2021Review
- Respiratory Virus Co-infection in Acute Respiratory Infections in Children.Current infectious disease reports · 2020Review
- Epidemiology of Infections and Development of Asthma.Immunology and allergy clinics of North America · 2019Review
- Article
- Evidence that a primary anti-viral stimulation of the immune response by OM-85 reduces susceptibility to a secondary respiratory bacterial infection in mice.Italian journal of pediatrics · 2018Article
- Streptococcus pneumoniae colonization of the nasopharynx is associated with increased severity during respiratory syncytial virus infection in young children.Respirology (Carlton, Vic.) · 2018Article
- PCV13 vaccination impact: A multicenter study of pneumonia in 10 pediatric hospitals in Argentina.PloS one · 2018Article
- Community acquired pneumonia incidence among children less than 5 years of age in Concordia, Argentina: vaccination impact.Revista panamericana de salud publica = Pan American journal of public health · 2018Article
- Elucidation of Bacterial Pneumonia-Causing Pathogens in Patients with Respiratory Viral Infection.Tuberculosis and respiratory diseases · 2017Article
- Viral-bacterial co-infections in the respiratory tract.Current opinion in microbiology · 2017Review
- The contributions of allergic sensitization and respiratory pathogens to asthma inception.The Journal of allergy and clinical immunology · 2016Review
- Review of Non-Bacterial Infections in Respiratory Medicine: Viral Pneumonia.Archivos de bronconeumologia · 2015Review
- Macrophage adaptation in airway inflammatory resolution.European respiratory review : an official journal of the European Respiratory Society · 2015Review
- Changes in microbiota during experimental human Rhinovirus infection.BMC infectious diseases · 2015Article
- Infection in severe asthma exacerbations and critical asthma syndrome.Clinical reviews in allergy & immunology · 2015Review
- Virus-induced secondary bacterial infection: a concise review.Therapeutics and clinical risk management · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial coinfections occur in respiratory viral infections, but the attack rates and the clinical profile are not clear. The aim of this study was to determine bacterial coinfections in children hospitalized for acute expiratory wheezing with defined viral etiology. A total of 220 children aged 3 months to 16 years were investigated. The viral etiology of wheezing was confirmed by viral culture, antigen detection, serologic investigation, and/or PCR. Specific antibodies to common respiratory bacteria were measured from acute and convalescent serum samples. All children were examined clinically for acute otitis media, and subgroups of children were examined radiologically for sinusitis and pneumonia. Rhinovirus (32%), respiratory syncytial virus (31%), and enteroviruses (31%) were the most common causative viruses. Serologic evidence of bacterial coinfection was found in 18% of the children. Streptococcus pneumoniae (8%) and Mycoplasma pneumoniae (5%) were the most common causative bacteria. Acute otitis media was diagnosed in 44% of the children. Chest radiographs showed alveolar infiltrates in 10%, and paranasal radiographs and clinical signs showed sinusitis in 17% of the older children studied. Leukocyte counts and serum C-reactive protein levels were low in a great majority of patients. Viral lower respiratory tract infection in children is often associated with bacterial-type upper respiratory tract infections. However, coexisting bacterial lower respiratory tract infections that induce systemic inflammatory response are seldom detected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.