ReviewHeart failure reviews2006
Zinc balance and medications commonly used in the management of heart failure.
Review in Heart failure reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis.BioMed research international · 2018Pooled it
- Hemodynamic-Guided Nutrition Support in Pediatric Congenital Heart Disease.Current nutrition reports · 2026Review
- Impact of Zinc Deficiency in Heart Failure Patients According to Ejection Fraction Subtype - An Observational Study.Circulation reports · 2026Article
- Dietary Zn-Recent Advances in Studies on Its Bioaccessibility and Bioavailability.Molecules (Basel, Switzerland) · 2025Review
- The Effects of Different Treatments on Serum Trace Element Levels in Dogs with Heart Failure.Animals : an open access journal from MDPI · 2024Article
- Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study.BMC pediatrics · 2024Article
- Role of zinc in health and disease.Clinical and experimental medicine · 2024Review
- Cardiovascular Diseases and Zinc.Biological trace element research · 2023Review
- A review and guide to nutritional care of the infant with established bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?Journal of internal medicine · 2022Review
- The Cardiac Ryanodine Receptor Provides a Suitable Pathway for the Rapid Transport of Zinc (ZnCells · 2022Article
- Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19.The British journal of nutrition · 2022Review
- Association between COVID-19 and angiotensin-converting enzyme inhibitors with the spotlight on zinc: an opinion.Annals of medicine · 2021Article
- Zinc as a Biomarker of Cardiovascular Health.Frontiers in nutrition · 2021Review
- Micronutrient status during paediatric critical illness: A scoping review.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Zinc as nutritional intervention and prevention measure for COVID-19 disease.BMJ nutrition, prevention & health · 2020Article
- Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases.Acta pharmacologica Sinica · 2018Review
- Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update.Pharmaceutics · 2018Review
- The Critical Roles of Zinc: Beyond Impact on Myocardial Signaling.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2015Review
- Biological consequences of zinc deficiency in the pathomechanisms of selected diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure (HF) is a prevalent syndrome resulting in a high mortality rate. HF may be associated with zinc deficiency through a reduction in dietary intake, decreased absorption due to gastrointestinal edema, impaired motility or intestinal zinc losses. Diseases concomitant with HF such as diabetes mellitus (DM) and hypertension may enhance zinc deficiency. Medications given for HF may affect zinc metabolism in different ways. It was shown that thiazides may cause zincuria and a decrease in tissue zinc concentration. There is conflicting evidence about furosemide, even though patients with chronic furosemide treatment showed low tissue zinc levels in autopsies. Treatment with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) resulted in zincuria and zinc deficiency, but this outcome was not consistent in all studies. Beta-blockers did not alter plasma zinc concentration. Matrix metalloproteinases (MMPs) and ACE are zinc-containing enzymes, which play a role in the process of remodeling in HF. It was shown that ACE inhibitors may inhibit the activity of different MMPs. The exact interrelationship between HF, zinc-containing enzymes, zinc deficiency and the clinical manifestation of HF has to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.