ArticleNature medicine2006
Experimental febrile seizures are precipitated by a hyperthermia-induced respiratory alkalosis.
Article in Nature medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it, 290 citations in OpenAlex.
- Decreased Brain pH Correlated With Progression of Alzheimer Disease Neuropathology: A Systematic Review and Meta-Analyses of Postmortem Studies.The international journal of neuropsychopharmacology · 2024Pooled it
- The use of carbogen for interruption of febrile seizures - the randomized controlled CARDIF trial.PloS one · 2025Trial
- Trial
- Copeptin as a serum biomarker of febrile seizures.PloS one · 2015Trial
- CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study.Journal of translational medicine · 2013Trial
- Detecting activity-evoked pH changes in human brain.Proceedings of the National Academy of Sciences of the United States of America · 2012Trial
- Ambient temperature and pediatric seizure hospitalization: a time-stratified analysis in a national dataset.Pediatric research · 2026Article
- Carbogen Inhalation Therapy for Epileptic Seizures: Mechanisms, Evidence, and Future Directions.CNS neuroscience & therapeutics · 2025Review
- Developmental progression of respiratory dysfunction in a mouse model of Dravet syndrome.JCI insight · 2025Article
- The Exchange Breathing Method for Seizure Intervention: A Historical and Scientific Review of Epilepsy and Its Evolving Therapeutic Paradigms.Journal of personalized medicine · 2025Review
- Association between wet-bulb globe temperature and epilepsy: a space-time-stratified case-crossover study in Taiwan.Tropical medicine and health · 2025Article
- Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025Article
- Inhalation of 5% COActa epileptologica · 2025Article
- Association of Hypocapnia With Febrile Seizures: A Cross-Sectional Observational Study.Cureus · 2025Article
- Anemia, inflammation, circadian rhythm and season effects in febrile convulsions.Northern clinics of Istanbul · 2025Article
- Review
- The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures.American journal of respiratory cell and molecular biology · 2024Article
- Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCOJournal of neurochemistry · 2024Article
- NHFrontiers in physiology · 2024Article
- Electrophysiological characterization of a CaMolecular brain · 2023Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Febrile seizures are frequent during early childhood, and prolonged (complex) febrile seizures are associated with an increased susceptibility to temporal lobe epilepsy. The pathophysiological consequences of febrile seizures have been extensively studied in rat pups exposed to hyperthermia. The mechanisms that trigger these seizures are unknown, however. A rise in brain pH is known to enhance neuronal excitability. Here we show that hyperthermia causes respiratory alkalosis in the immature brain, with a threshold of 0.2-0.3 pH units for seizure induction. Suppressing alkalosis with 5% ambient CO2 abolished seizures within 20 s. CO2 also prevented two long-term effects of hyperthermic seizures in the hippocampus: the upregulation of the I(h) current and the upregulation of CB1 receptor expression. The effects of hyperthermia were closely mimicked by intraperitoneal injection of bicarbonate. Our work indicates a mechanism for triggering hyperthermic seizures and suggests new strategies in the research and therapy of fever-related epileptic syndromes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.