ArticleBritish journal of cancer2006
Heritability of DNA-damage-induced apoptosis and its relationship with age in lymphocytes from female twins.
Article in British journal of cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Prediction of the Acute or Late Radiation Toxicity Effects in Radiotherapy Patients Using Ex Vivo Induced Biodosimetric Markers: A Review.Journal of personalized medicine · 2020Review
- Combining CDKN1A gene expression and genome-wide SNPs in a twin cohort to gain insight into the heritability of individual radiosensitivity.Functional & integrative genomics · 2019Article
- Personalized Cancer Risk Assessments for Space Radiation Exposures.Frontiers in oncology · 2016Review
- Genetic polymorphisms in apoptosis-related genes and the prognosis of hepatocellular carcinoma.American journal of cancer research · 2015Article
- Deoxyribonucleic acid damage-associated biomarkers of ionising radiation: current status and future relevance for radiology and radiotherapy.The British journal of radiology · 2013Review
- Genetic and environmental influence on DNA strand break repair: a twin study.Environmental and molecular mutagenesis · 2013Article
- Genetic determinants of neuronal vulnerability to apoptosis.Cellular and molecular life sciences : CMLS · 2013Review
- Polymorphisms in apoptosis-related genes and TP53 mutations in non-small cell lung cancer.Journal of Korean medical science · 2011Article
- Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.Pharmacogenetics and genomics · 2011Article
- Gene polymorphisms, apoptotic capacity and cancer risk.Human genetics · 2009Review
- Evidence for significant heritability of apoptotic and cell cycle responses to ionising radiation.Human genetics · 2008Article
- Heritability of susceptibility to ionizing radiation-induced apoptosis of human lymphocyte subpopulations.International journal of radiation oncology, biology, physics · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Apoptosis is a physiological form of cell death important in normal processes such as morphogenesis and the functioning of the immune system. In addition, defects in the apoptotic process play a major role in a number of important areas of disease, such as autoimmune diseases and cancer. DNA-damage-induced apoptosis plays a vital role in the maintenance of genomic stability by the removal of damaged cells. Previous studies of the apoptotic response (AR) to radiation-induced DNA damage of lymphoid cells from individuals carrying germline TP53 mutations have demonstrated a defective AR compared with normal controls. We have also previously demonstrated that AR is reduced as individuals age. Results from the current study on 108 twins aged 18-80 years confirm these earlier findings that the AR of lymphoid cells to DNA damage is significantly reduced with increasing age. In addition this twin study shows, for the first time, that DNA-damage-induced AR has a strong degree of heritability of 81% (95% confidence interval 67-89%). The vital role of DNA-damage-induced apoptosis in maintaining genetic stability, its relationship with age and its strong heritability underline the importance of this area of biology and suggest areas for further study.
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