ArticleProceedings of the National Academy of Sciences of the United States of America2006
Microtubule bundling and nested buckling drive stripe formation in polymerizing tubulin solutions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
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- Intermittent F-actin Perturbations by Magnetic Fields Inhibit Breast Cancer Metastasis.Research (Washington, D.C.) · 2023Article
- Competing instabilities reveal how to rationally design and control active crosslinked gels.Nature communications · 2022Article
- Radial alignment of microtubules through tubulin polymerization in an evaporating droplet.PloS one · 2020Article
- Tunable corrugated patterns in an active nematic sheet.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Microtubule teardrop patterns.Scientific reports · 2015Article
- Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.PloS one · 2014Article
- Emergent complexity of the cytoskeleton: from single filaments to tissue.Advances in physics · 2013Review
- Motor transport of self-assembled cargos in crowded environments.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Macromolecular crowding regulates assembly of mRNA stress granules after osmotic stress: new role for compatible osmolytes.The Journal of biological chemistry · 2012Article
- Rapid assembly and collective behavior of microtubule bundles in the presence of polyamines.Biophysical journal · 2011Article
- Endocytic membrane fusion and buckling-induced microtubule severing mediate cell abscission.Journal of cell science · 2011Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various mechanisms govern pattern formation in chemical and biological reaction systems, giving rise to structures with distinct morphologies and physical properties. The self-organization of polymerizing microtubules (MTs) is of particular interest because of its implications for biological function. We report a study of the microscopic structure and properties of the striped patterns that spontaneously form in polymerizing tubulin solutions and propose a mechanism driving this assembly. Microscopic observations reveal that the pattern comprises wave-like MT bundles. The retardance of the solution and the fluorescence intensity of labeled MTs vary periodically in space, suggesting a coincident periodic variation in MT alignment and density. This wave-like structure forms through the development and coordinated buckling of initially aligned MT bundles. Both static magnetic fields and convective flow can induce the initial alignment. The nesting of the buckled MT bundles gives rise to density variations that are in quantitative accord with the data. We further propose that the buckling wavelength is selected by a balance between the bending energy of the bundles and the elastic energy of the MT network surrounding them. These studies reveal a unique physical chemical mechanism by which mechanical buckling couples with protein polymerization to produce macroscopic patterns. Self-organization of this type may be important to the formation of certain biological structures.
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