ReviewCerebellum (London, England)2006
Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell.
Review in Cerebellum (London, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Progesterone treatment shows greater protection in brain vs. retina in a rat model of middle cerebral artery occlusion: Progesterone receptor levels may play an important role.Restorative neurology and neuroscience · 2016Article
- Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms.Cellular and molecular life sciences : CMLS · 2014Article
- Purkinje cell maturation participates in the control of oligodendrocyte differentiation: role of sonic hedgehog and vitronectin.PloS one · 2012Article
- Steroidogenic acute regulatory protein expression in the central nervous system.Frontiers in endocrinology · 2011Article
- Estradiol meets notch signaling in developing neurons.Frontiers in endocrinology · 2011Article
- Biosynthesis, mode of action, and functional significance of neurosteroids in the purkinje cell.Frontiers in endocrinology · 2011Article
- Brain microglia express steroid-converting enzymes in the mouse.The Journal of steroid biochemistry and molecular biology · 2008Article
- The cerebellum, cerebellar disorders, and cerebellar research--two centuries of discoveries.Cerebellum (London, England) · 2008Review
- Expression, localization and possible actions of 25-Dx, a membraneassociated putative progesterone-binding protein, in the developing Purkinje cell of the cerebellum: a new insight into the biosynthesis, metabolism and multiple actions of progesterone as a neurosteroid.Cerebellum (London, England) · 2008Review
- Endocrine disrupting polyhalogenated organic pollutants interfere with thyroid hormone signalling in the developing brain.Cerebellum (London, England) · 2008Review
- Hormonal regulation of cerebellar development and plasticity.Cerebellum (London, England) · 2008Article
- Mode of action and functional significance of estrogen-inducing dendritic growth, spinogenesis, and synaptogenesis in the developing Purkinje cell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Neurosteroids in the Purkinje cell: biosynthesis, mode of action and functional significance.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Probing undiscovered neurosubstances that play important roles in the regulation of cerebellar function is essential for the progress of our understanding of the cerebellum. New findings over the past decade have established that the cerebellum as well as other brain regions synthesizes steroids de novo from cholesterol through mechanisms at least partly independent of peripheral steroidogenic glands. Such steroids synthesized de novo in the brain are called neurosteroids. Recently the Purkinje cell, a cerebellar neuron, has been identified as a major site for neurosteroid formation in the brain. This is the first demonstration of de novo neuronal neurosteroidogenesis in the brain. In mammals, the Purkinje cell actively synthesizes progesterone de novo from cholesterol during neonatal life, when cerebellar cortical formation occurs. 3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) is metabolized from progesterone in the neonatal cerebellum. Estrogen formation in the Purkinje cell may also occur in the neonate. Subsequently, recent studies on mammals using the Purkinje cell have demonstrated organizing actions of neurosteroids. Both progesterone and estradiol promote dendritic growth, spinogenesis and synaptogenesis via each cognate nuclear receptor in Purkinje neurons. Allopregnanolone is also involved in Purkinje and granule cell survival. Thus the Purkinje cell serves as an excellent cellular model for understanding the formation of cerebellar neuronal circuit in relation to organizing actions of neurosteroids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.