ReviewInternational reviews of immunology
T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity.
Review in International reviews of immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells.Science advances · 2025Article
- Development of protein-polymer conjugate nanoparticles for modulation of dendritic cell phenotype and antigen-specific CD4 T cell responses.ACS applied polymer materials · 2023Article
- Strength and Numbers: The Role of Affinity and Avidity in the 'Quality' of T Cell Tolerance.Cells · 2021Review
- Mature Dendritic Cells May Promote High-Avidity Tuning of Vaccine T Cell Responses.Frontiers in immunology · 2020Article
- Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.PloS one · 2010Article
- Reduced skin homing by functional Treg in vitiligo.Pigment cell & melanoma research · 2010Article
- CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function.The Journal of experimental medicine · 2010Article
- Changes in autoreactive T cell avidity during type 1 diabetes development.Clinical immunology (Orlando, Fla.) · 2009Article
- Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition.Cancer immunology, immunotherapy : CII · 2009Article
- Retrogenic modeling of experimental allergic encephalomyelitis associates T cell frequency but not TCR functional affinity with pathogenicity.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- T-cell migration: a naive paradigm?Immunology · 2007Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Thymic T-cell selection mechanisms generate a cross-reactive, self-MHC restricted peripheral T-cell pool. Affinity and avidity are of profound influence on this selection and the generation of immunity. Autoreactive T cells can escape thymic deletion by lowering their avidity and retain this "tuned" state in the periphery. Upon activation, tuned T cells can cause autoimmunity, while immunotherapeutic strategies may be hampered by existing T-cell tolerance. The regulation of T-cell avidity and tuning therefore determines the balance between tolerance and autoimmunity and should be taken into account in the design of therapeutic strategies aimed at T-cell reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.