Trial reportCell stress & chaperones2006
Human resting extracellular heat shock protein 72 concentration decreases during the initial adaptation to exercise in a hot, humid environment.
Trial report in Cell stress & chaperones, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Moderate- and high-intensity exhaustive exercise in the heat induce a similar increase in monocyte Hsp72.Cell stress & chaperones · 2015Trial
- Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.BioMed research international · 2015Trial
- Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure.Cell stress & chaperones · 2014Trial
- Heat and exercise acclimation increases intracellular levels of Hsp72 and inhibits exercise-induced increase in intracellular and plasma Hsp72 in humans.Cell stress & chaperones · 2010Trial
- Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review.The journal of physiological sciences : JPS · 2023Article
- Carbohydrate, but not fat, oxidation is reduced during moderate-intensity exercise performed in 33 vs. 18 °C at matched heart rates.European journal of applied physiology · 2023Article
- Observations of TCRVβ Gene Expression in Rats with Dampness Syndrome.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Exercise training-induced changes in inflammatory mediators and heat shock proteins in young tennis players.Journal of sports science & medicine · 2013Article
- Plasma Hsp72 (HSPA1A) and Hsp27 (HSPB1) expression under heat stress: influence of exercise intensity.Cell stress & chaperones · 2012Article
- No endogenous circadian rhythm in resting plasma Hsp72 concentration in humans.Cell stress & chaperones · 2009Article
- Response of plasma IL-6 and its soluble receptors during submaximal exercise to fatigue in sedentary middle-aged men.Cell stress & chaperones · 2008Article
- The effect of 15 consecutive days of heat-exercise acclimation on heat shock protein 70.Cell stress & chaperones · 2008Article
- Heat shock protein 72 response to exercise in humans.Sports medicine (Auckland, N.Z.) · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock protein (Hsp) 72 is a cytosolic protein that also is present in the circulation. Extracellular Hsp72 (eHsp72) is inducible by exercise and is suggested to act as a danger signal to the immune system. The adaptive response of eHsp72 to repeated exercise-heat exposures in humans remains to be determined. An intracellular animal study found a reduced Hsp72 response, with no change in resting levels, during heat stress after a single day of passive heat acclimation. The current study therefore tested whether adaptations in human eHsp72 levels would similarly occur 24 hours after a single exercise-heat exposure. Seven males completed cycle exercise (42.5% V(O2peak) for 2 hours) in a hot, humid environment (38 degrees C, 60% relative humidity) on each of 2 consecutive days. Blood samples were obtained from an antecubital vein before exercise and 0 hours and 22 hours postexercise for the analysis of eHsp72. Exercise-heat stress resulted in enhanced eHsp72, with a similar absolute increase found on both days (day 1: 1.26 ng/mL [0.80 ng/mL]; day 2: 1.29 ng/mL [1.60 ng/mL]). Resting eHsp72 decreased from rest on day 1 to day 2's 22-hour postexercise sample (P < 0.05). It is suggested that the reduction in resting eHsp72 after 2 consecutive exercise-heat exposures is possibly due to an enhanced removal from the circulation, for either immunoregulatory functions, or for improved cellular stress tolerance in this initial, most stressful period of acclimation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.