ReviewHistochemistry and cell biology2006
The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants.
Review in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- Clinical relevance of the compartments and lymphocyte subsets in the human spleen.Cell and tissue research · 2025Article
- Germinal Center B Cells are Uniquely Targeted by Antibody-Suppressor CXCR5Transplantation direct · 2025Article
- Human circulating CD24Nature cardiovascular research · 2023Article
- Asplenia and spleen hypofunction.Nature reviews. Disease primers · 2022Review
- Plasma cells, plasmablasts, and AIDHistochemistry and cell biology · 2020Article
- Resident Memory B Cells.Viral immunology · 2020Review
- Innate B Cells: the Archetype of Protective Immune Cells.Clinical reviews in allergy & immunology · 2020Review
- Article
- Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.Toxicologic pathology · 2019Article
- Tertiary Lymphoid Structures: Autoimmunity Goes Local.Frontiers in immunology · 2018Review
- Capillary networks and follicular marginal zones in human spleens. Three-dimensional models based on immunostained serial sections.PloS one · 2018Article
- Adrenergic-mediated loss of splenic marginal zone B cells contributes to infection susceptibility after stroke.Nature communications · 2017Article
- High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function.Frontiers in immunology · 2017Review
- Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity.Immunological reviews · 2016Review
- Human spleen microanatomy: why mice do not suffice.Immunology · 2015Review
- Sinusoidal immunity: macrophages at the lymphohematopoietic interface.Cold Spring Harbor perspectives in biology · 2014Review
- Contributions of B cells to lupus pathogenesis.Molecular immunology · 2014Review
- Article
- B lymphocyte compartments in the human splenic red pulp: capillary sheaths and periarteriolar regions.Histochemistry and cell biology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the spleen in B memory cell development and maintenance is attracting increased attention. Studies in mice and rats have indicated that memory functions are associated with large B cells residing in the marginal zone (MZ) of the spleen. Although the cellular composition of the MZ is relatively well known in these species, controversies exist about the function of MZ B cells, their dependence on the presence of the spleen and the stage at which their development branches from that of recirculating follicular B cells. Additional confusion has arisen with respect to MZ B cells in humans, because the microscopic anatomy of the human splenic MZ differs decisively from that of rodents. Several recent publications indicate that the functional and migratory properties of human MZ B cells may be species-specific. The hypothesis derived from these publications and from our immunohistological observations implies that at least a major number of human splenic CD27(+) MZ B cells are migratory. Phenotypic data suggest a recirculation pathway between the spleen and mucosal tissues in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.