ArticleClinical rheumatology2007
Leptin levels in Henoch-Schönlein purpura.
Article in Clinical rheumatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Serum leptin, a potential predictor of long-term angiographic progression in Takayasu's arteritis.International journal of rheumatic diseases · 2019Article
- Serum level of advanced oxidation protein products (AOPPs) in patients with Henoch-Schonlein purpura and its relationship with aberrant glycosylation of IgA1 and Cosmc mRNA expression.International journal of dermatology · 2019Observational
- Inducible nitric oxide synthase gene polymorphisms are associated with a risk of nephritis in Henoch-Schönlein purpura children.European journal of pediatrics · 2017Article
- Ghrelin and adipokines as circulating markers of disease activity in patients with Takayasu arteritis.Arthritis research & therapy · 2012Article
- Serum and urine nitric oxide levels in children with Henoch-Schonlein purpura during activity and remission: a study from North India.Rheumatology international · 2009Article
- Cerebral vasculitis in a child with Henoch-Schönlein purpura and familial Mediterranean fever.Clinical rheumatology · 2007Article
- ANCA-associated Vasculitis in a Case of Congenital Leptin Deficiency.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this paper is to assess the possible role of nitric oxide (NO) and leptin in Henoch-Schönlein purpura (HSP). We investigated the serum leptin and total nitrite levels in 22 children with HSP in the acute phase and after remission and in 20 age- and sex-matched healthy control. Serum leptin levels (nanograms per milliliter; median, min-max) were statistically higher in the acute phase (12.9, 9.1-19.5) than those in the remission phase (6.1, 3.7-10.5, p<0.001) and in the control group (4.9, 3.8-7.5, p<0.001). Also, serum nitrite levels (micromole per liter; median, min-max) were higher in children in the acute phase (45.0, 32.0-60.0) compared to those in remission phase (30.5, 23.0-48.0) and in the control group (29.5, 18.0-38.0) (p<0.001, p<0.001, respectively). There was a positive correlation between serum leptin and total nitrite levels (r=0.65, p<0.001). We have demonstrated that serum leptin and NO levels were increased during the acute phase in children with HSP, and returned to normal levels in remission. We suggest that leptin and NO may have a role in the immunoinflammatory process of HSP, especially in the acute phase. Further studies are needed to clearly establish the roles of leptin and NO in the pathogenesis of HSP.
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