ArticleGenetics2006
The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum.Cold Spring Harbor perspectives in biology · 2023Review
- The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER.Cell reports · 2023Article
- A conserved guided entry of tail-anchored pathway is involved in the trafficking of a subset of membrane proteins in Plasmodium falciparum.PLoS pathogens · 2021Article
- A homolog of GuidedEntry of Tail-anchored proteins3 functions in membrane-specific protein targeting in chloroplasts of Arabidopsis.The Plant cell · 2021Article
- Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans.Scientific reports · 2021Article
- Endoplasmic reticulum membrane receptors of the GET pathway are conserved throughout eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Ways of Tails: the GET Pathway and more.The protein journal · 2019Review
- The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.Development (Cambridge, England) · 2018Article
- Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer.Cell reports · 2017Article
- Mutations in the ArsA ATPase that restore interaction with the ArsD metallochaperone.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2014Article
- Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked.Journal of cell science · 2013Article
- Article
- Regulation of chaperone effects on a yeast prion by cochaperone Sgt2.Molecular and cellular biology · 2012Article
- A portrait of the GET pathway as a surprisingly complicated young man.Trends in biochemical sciences · 2012Review
- Nucleotide-dependent mechanism of Get3 as elucidated from free energy calculations.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A directed RNAi screen based on larval growth arrest reveals new modifiers of C. elegans insulin signaling.PloS one · 2012Article
- Pathways of arsenic uptake and efflux.Current topics in membranes · 2012Article
- Tail-anchored membrane protein insertion into the endoplasmic reticulum.Nature reviews. Molecular cell biology · 2011Review
- The mechanism of tail-anchored protein insertion into the ER membrane.Molecular cell · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of cellular membrane dynamics is crucial for maintaining proper cell growth and division. The Cdc48-Npl4-Ufd1 complex is required for several regulated membrane-associated processes as part of the ubiquitin-proteasome system, including ER-associated degradation and the control of lipid composition in yeast. In this study we report the results of a genetic screen in Saccharomyces cerevisiae for extragenic suppressors of a temperature-sensitive npl4 allele and the subsequent analysis of one suppressor, GET3/ARR4. The GET3 gene encodes an ATPase with homology to the regulatory component of the bacterial arsenic pump. Mutants of GET3 rescue several phenotypes of the npl4 mutant and transcription of GET3 is coregulated with the proteasome, illustrating a functional relationship between GET3 and NPL4 in the ubiquitin-proteasome system. We have further found that Get3 biochemically interacts with the trans-membrane domain proteins Get1/Mdm39 and Get2/Rmd7 and that Deltaget3 is able to suppress phenotypes of get1 and get2 mutants, including sporulation defects. In combination, our characterization of GET3 genetic and biochemical interactions with NPL4, GET1, and GET2 implicates Get3 in multiple membrane-dependent pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.