ArticleGenetics2006
A first-generation metric linkage disequilibrium map of bovine chromosome 6.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
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- Functional characterisation of the bovine neuropeptide Y gene promoter and evaluation of the transcriptional activities of promoter haplotypes.Molecular biology reports · 2012Article
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- Linkage disequilibrium and signatures of selection on chromosomes 19 and 29 in beef and dairy cattle.Animal genetics · 2008Article
- A second generation genetic map for rainbow trout (Oncorhynchus mykiss).BMC genetics · 2008Article
- Linkage disequilibrium compared between five populations of domestic sheep.BMC genetics · 2008Article
- Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle.Genetics · 2008Article
- Extent of genome-wide linkage disequilibrium in Australian Holstein-Friesian cattle based on a high-density SNP panel.BMC genomics · 2008Article
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- Associations between 2 paternal casein haplotypes and milk yield traits of Swiss Fleckvieh cattle.Journal of applied genetics · 2008Article
- Genomewide analysis of secretory activation in mouse models.Journal of mammary gland biology and neoplasia · 2007Article
- Whole genome linkage disequilibrium maps in cattle.BMC genetics · 2007Article
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Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We constructed a metric linkage disequilibrium (LD) map of bovine chromosome 6 (BTA6) on the basis of data from 220 SNPs genotyped on 433 Australian dairy bulls. This metric LD map has distances in LD units (LDUs) that are analogous to centimorgans in linkage maps. The LD map of BTA6 has a total length of 8.9 LDUs. Within the LD map, regions of high LD (represented as blocks) and regions of low LD (steps) are observed, when plotted against the integrated map in kilobases. At the most stringent block definition, namely a set of loci with zero LDU increase over the span of these markers, BTA6 comprises 40 blocks, accounting for 41% of the chromosome. At a slightly lower stringency of block definition (a set of loci covering a maximum of 0.2 LDUs on the LD map), up to 81% of BTA6 is spanned by 46 blocks and with 13 steps that are likely to reflect recombination hot spots. The mean swept radius (the distance over which LD is likely to be useful for mapping) is 13.3 Mb, confirming extensive LD in Holstein-Friesian dairy cattle, which makes such populations ideal for whole-genome association studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.