ArticleGenetics2006
A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- SDS-22 stabilizes GSP-1/-2 PP1 subunits contributing to polarity establishment in C. elegans embryos.EMBO reports · 2025Article
- Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.PLoS biology · 2024Article
- The protein tyrosine phosphatase PPH-7 is required for fertility and embryonic development in C. elegans at elevated temperatures.FEBS open bio · 2024Article
- PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.The Journal of cell biology · 2022Article
- Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms.Development (Cambridge, England) · 2019Article
- Toward Identifying Subnetworks from FBF Binding Landscapes inG3 (Bethesda, Md.) · 2019Article
- Spindle assembly checkpoint strength is linked to cell fate in the Caenorhabditis elegans embryo.Molecular biology of the cell · 2018Article
- De novo mutation inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- A Single-Cell Biochemistry Approach Reveals PAR Complex Dynamics during Cell Polarization.Developmental cell · 2017Article
- Regulation of Cell Polarity by PAR-1/MARK Kinase.Current topics in developmental biology · 2017Review
- Mechanisms of polarity protein expression control.Current opinion in cell biology · 2016Review
- Cdk1 plays matchmaker for the Polo-like kinase and its activator SPAT-1/Bora.Cell cycle (Georgetown, Tex.) · 2015Article
- CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.PloS one · 2015Article
- Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms?Open biology · 2013Review
- Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy.Nature cell biology · 2013Article
- 'Goldilocks' suppressor screen identifies web of polarity regulators.Nature cell biology · 2013Article
- The PAR network: redundancy and robustness in a symmetry-breaking system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Genetics · 2012Article
- Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.PLoS genetics · 2012Article
- RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PAR proteins play an essential role in establishing and maintaining cell polarity. While their function is conserved across species, little is known about their regulators and effectors. Here we report the identification of 13 potential components of the C. elegans PAR polarity pathway, identified in an RNAi-based, systematic screen to find suppressors of par-2(it5ts) lethality. Most of these genes are conserved in other species. Phenotypic analysis of double-mutant animals revealed that some of the suppressors can suppress lethality associated with the strong loss-of-function allele par-2(lw32), indicating that they might impinge on the PAR pathway independently of the PAR-2 protein. One of these is the gene nos-3, which encodes a homolog of Drosophila Nanos. We find that nos-3 suppresses most of the phenotypes associated with loss of par-2 function, including early cell division defects and maternal-effect sterility. Strikingly, while PAR-1 activity was essential in nos-3; par-2 double mutants, its asymmetric localization at the posterior cortex was not restored, suggesting that the function of PAR-1 is independent of its cortical localization. Taken together, our results identify conserved components that regulate PAR protein function and also suggest a role for NOS-3 in PAR protein-dependent cell polarity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.