ArticleGenetics2006
The mechanism of secondary nondisjunction in Drosophila melanogaster females.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
- B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster.Current biology : CB · 2023Article
- Site-specific transgenesis of the Drosophila melanogaster Y-chromosome using CRISPR/Cas9.Insect molecular biology · 2019Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Review
- Article
- The Centenary of GENETICS: Bridges to the Future.Genetics · 2016Article
- Behavior of aberrant chromosome configurations in Drosophila melanogaster female meiosis I.G3 (Bethesda, Md.) · 2014Article
- Article
- Nondisjunctional segregations in Drosophila female meiosis I are preceded by homolog malorientation at metaphase arrest.Genetics · 2013Article
- Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.PLoS genetics · 2011Article
- Article
- Heterochromatin-mediated association of achiasmate homologs declines with age when cohesion is compromised.Genetics · 2009Article
- Article
- Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes.PLoS genetics · 2009Article
- Changing partners: moving from non-homologous to homologous centromere pairing in meiosis.Trends in genetics : TIG · 2008Review
- On the origin of trisomy 21 Down syndrome.Molecular cytogenetics · 2008Article
- Article
- The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle.PLoS biology · 2007Article
- Spindle assembly in the oocytes of mouse and Drosophila--similar solutions to a problem.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bridges (1916) observed that X chromosome nondisjunction was much more frequent in XXY females than it was in genetically normal XX females. In addition, virtually all cases of X nondisjunction in XXY females were due to XX <--> Y segregational events in oocytes in which the two X chromosomes had failed to undergo crossing over. He referred to these XX <--> Y segregation events as "secondary nondisjunction." Cooper (1948) proposed that secondary nondisjunction results from the formation of an X-Y-X trivalent, such that the Y chromosome directs the segregation of two achiasmate X chromosomes to opposite poles on the first meiotic spindle. Using in situ hybridization to X and YL chromosomal satellite sequences, we demonstrate that XX <--> Y segregations are indeed presaged by physical associations of the X and Y chromosomal heterochromatin. The physical colocalization of the three sex chromosomes is observed in virtually all oocytes in early prophase and maintained at high frequency until midprophase in all genotypes examined. Although these XXY associations are usually dissolved by late prophase in oocytes that undergo X chromosomal crossing over, they are maintained throughout prophase in oocytes with nonexchange X chromosomes. The persistence of such XXY associations in the absence of exchange presumably facilitates the segregation of the two X chromosomes and the Y chromosome to opposite poles on the developing meiotic spindle. Moreover, the observation that XXY pairings are dissolved at the end of pachytene in oocytes that do undergo X chromosomal crossing over demonstrates that exchanges can alter heterochromatic (and thus presumably centromeric) associations during meiotic prophase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.