ArticleThe American journal of pathology2006
Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.Cells · 2019Review
- 17β-Estradiol sensitizes ovarian surface epithelium to transformation by suppressing Disabled-2 expression.Scientific reports · 2017Article
- Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice.Frontiers in cell and developmental biology · 2016Review
- miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.Oncogene · 2014Article
- Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues.BMC developmental biology · 2013Article
- Article
- Technical challenges and limitations of current mouse models of ovarian cancer.Journal of ovarian research · 2012Article
- BRCA1-mediated signaling pathways in ovarian carcinogenesis.Functional & integrative genomics · 2012Article
- Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.Oncogene · 2012Article
- Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.Nature genetics · 2011Article
- Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.The Journal of clinical investigation · 2010Article
- Precursor lesions of high-grade serous ovarian carcinoma: morphological and molecular characteristics.Journal of oncology · 2010Article
- Article
- Migrating with myosin VI.The American journal of pathology · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Disabled-2 (Dab2) is a phosphoprotein involved in cellular signal transduction and endocytic trafficking. The expression of Dab2 is frequently lost or suppressed in several epithelial tumors, and studies of its cellular function and growth suppressive activity when re-expressed in cancer cells led to the suggestion that Dab2 is a tumor suppressor. A role for Dab2 in epithelial cell positioning organization was derived from study of knockout mice: homozygous deletion of dab2 results in early embryonic lethality due to the disorganization of the primitive endoderm, the first epithelium in early embryos. We now report that dab2 heterozygous mice develop uterine hyperplasia and ovarian preneoplastic morphological changes at a high frequency. Crossing into a p53(-/-) background unexpectedly produced few female dab2(+/-):p53(-/-) mice, while the male dab2(+/-):p53(-/-) were born at the expected Mendelian frequency. The tumor-prone phenotype of dab2(+/-) mice provides additional support for a role of human Dab2 as a tumor suppressor, and the sex-biased embryonic lethality suggests a genetic interaction between p53 and dab2 genes in female mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.