ArticleThe American journal of pathology2006
Pathogenic role for virus-specific CD4 T cells in mice with coronavirus-induced acute encephalitis.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- T helper 1 effector memory CD4Cell reports · 2023Article
- Review
- Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis.Frontiers in immunology · 2019Review
- Microglia are required for protection against lethal coronavirus encephalitis in mice.The Journal of clinical investigation · 2018Article
- Roles of regulatory T cells and IL-10 in virus-induced demyelination.Journal of neuroimmunology · 2017Review
- Virus-induced inflammasome activation is suppressed by prostaglandin DProceedings of the National Academy of Sciences of the United States of America · 2017Article
- M(IL-4) Tissue Macrophages Support Efficient Interferon-Gamma Production in Antigen-Specific CD8Frontiers in immunology · 2017Article
- Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination.Journal of visualized experiments : JoVE · 2016Article
- The cellular redox environment alters antigen presentation.The Journal of biological chemistry · 2014Article
- Virus-specific regulatory T cells ameliorate encephalitis by repressing effector T cell functions from priming to effector stages.PLoS pathogens · 2014Article
- Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Development of transgenic mice expressing a coronavirus-specific public CD4 T cell receptor.Journal of immunological methods · 2013Article
- Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.Journal of neuroinflammation · 2012Article
- Regulatory T cells in arterivirus and coronavirus infections: do they protect against disease or enhance it?Viruses · 2012Review
- IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.The Journal of experimental medicine · 2011Article
- Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- De novo recruitment of antigen-experienced and naive T cells contributes to the long-term maintenance of antiviral T cell populations in the persistently infected central nervous system.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Coronaviruses post-SARS: update on replication and pathogenesis.Nature reviews. Microbiology · 2009Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Acute viral encephalitis is believed to result from direct virus destruction of infected cells and from virus-induced host immune response, but the relative contribution of each remains largely unknown. For example, C57BL/6 (B6) mice infected with mouse hepatitis virus (JHM strain, JHMV) develop severe encephalitis, with death occurring within 7 days. Here, we show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease. We engineered a recombinant JHMV with mutations in the immunodominant CD4 T-cell epitope (rJ.M(Y135Q)). Infection of naïve B6 mice with this virus resulted in mild disease with no mortality. However, introduction of a CD4 T-cell epitope from Listeria monocytogenes into rJ.M(Y135Q) generated a highly virulent virus. The decrease in disease severity was not due to a switch from Th1 to Th2 predominance in rJ.M(Y135Q)-infected mice, an effect on CD8 T-cell function, or differential expression of tumor necrosis factor-alpha by JHMV-specific CD4 T cells. These results show that the response to a single virus-specific CD4 T-cell epitope may contribute to a pathogenic host response in the setting of acute viral disease and that abrogation of this response ameliorates clinical disease without diminishing virus clearance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.