ArticleThe American journal of pathology2006
Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Ambient Air Pollution Exposure and Outcomes in Patients Receiving Lung Transplant.JAMA network open · 2024Article
- Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.EBioMedicine · 2020Article
- c-Jun N-terminal kinase (JNK)-mediated induction of mSin1 expression and mTORC2 activation in mesenchymal cells during fibrosis.The Journal of biological chemistry · 2018Article
- Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation.The Journal of biological chemistry · 2016Article
- Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model.The Journal of thoracic and cardiovascular surgery · 2016Article
- IL-4 and IL-13 signaling in allergic airway disease.Cytokine · 2015Review
- Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation.Seminars in respiratory and critical care medicine · 2013Review
- Macrophage heterogeneity in respiratory diseases.Mediators of inflammation · 2013Review
- Expression of interleukin-4 and interleukin-13 and their receptors in colorectal cancer.International journal of colorectal disease · 2012Article
- Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts.American journal of respiratory and critical care medicine · 2012Article
- Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells.American journal of respiratory cell and molecular biology · 2011Article
- Review
- Integrating mechanisms of pulmonary fibrosis.The Journal of experimental medicine · 2011Review
- Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts.The American journal of pathology · 2011Article
- Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome.American journal of respiratory and critical care medicine · 2011Article
- Lung transplantation: infection, inflammation, and the microbiome.Seminars in immunopathology · 2011Review
- Analysis of cytokine pattern in exhaled breath condensate of lung transplant recipients with bronchiolitis obliterans syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Alcohol primes the airway for increased interleukin-13 signaling.Alcoholism, clinical and experimental research · 2009Article
- The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice.Respiratory research · 2008Article
- Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The pathogenesis of bronchiolitis obliterans (BO), a common and devastating obliterative disorder of small airways following lung transplantation, remains poorly understood. Lesions are characterized in their early stages by lymphocyte influx that evolves into dense fibrotic infiltrates. Airway specimens taken from patients with histological BO revealed infiltrating myofibroblasts, which strongly expressed the signaling chain of the high affinity interleukin-13 (IL-13) receptor IL-13Ralpha1. Because IL-13 has proinflammatory and profibrotic actions, a contributory role for IL-13 in BO development was examined using murine models of orthotopic and heterotopic tracheal transplantation. Compared with airway isografts, allografts exhibited a significant increase in relative IL-13 mRNA and protein levels. Allogeneic tracheas transplanted into IL-13-deficient mice were protected from BO in both transplant models. Flow cytometric analysis of orthotopic transplant tissue digests revealed markedly fewer infiltrating mononuclear phagocytes and CD3(+) T lymphocytes in IL-13-deficient recipients. Furthermore, protection from luminal obliteration, collagen deposition, and myofibroblast infiltration was observed in heterotopic airways transplanted into the IL-13(-/-) recipients. Transforming growth factor-beta1 expression was significantly decreased in tracheal allografts into IL-13(-/-) recipients, compared to wild-type counterparts. These human and murine data implicate IL-13 as a critical effector cytokine driving cellular recruitment and subsequent fibrosis in clinical and ex-perimental BO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.