ReviewThe American journal of pathology2006
Role of the Survivin gene in pathophysiology.
Review in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 109 citations in OpenAlex.
- Article
- Emerging Importance of Survivin in Stem Cells and Cancer: the Development of New Cancer Therapeutics.Stem cell reviews and reports · 2020Review
- Evaluation of survivin immunoexpression in the differentiation of high- and low-grade breast ductal carcinoma in situ.Einstein (Sao Paulo, Brazil) · 2018Article
- NF-κB suppresses apoptosis and promotes bladder cancer cell proliferation by upregulating survivin expression in vitro and in vivo.Scientific reports · 2017Article
- Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer?American journal of cancer research · 2017Review
- miRNA-335 and miRNA-182 affect the occurrence of tongue squamous cell carcinoma by targeting survivin.Oncology letters · 2016Article
- Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.Annals of rehabilitation medicine · 2016Article
- Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Survivin is expressed in degenerated nucleus pulposus cells and is involved in proliferation and the prevention of apoptosis in vitro.Molecular medicine reports · 2016Article
- Antenatal Dexamethasone For Women at Risk af Preterm Birth and Intraventricular Haemorrhage: What is the Truth?Iranian journal of pharmaceutical research : IJPR · 2016Article
- Correlation between survivin genetic polymorphisms and lung cancer susceptibility.International journal of clinical and experimental pathology · 2015Article
- Validation of analytical breast cancer microarray analysis in medical laboratory.Medical oncology (Northwood, London, England) · 2014Article
- Significance of intracellular localization of survivin in cervical squamous cell lesions: Correlation with disease progression.Oncology letters · 2014Article
- Targeting survivin in cancer.Cancer letters · 2013Review
- Polymorphisms of survivin and its protein expression are associated with colorectal cancer susceptibility in Chinese population.DNA and cell biology · 2013Article
- An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI).American journal of translational research · 2013Article
- [The oncofetal gene survivin - a possible target gene for regenerative therapy concepts in cartilaginous tissue].Der Orthopade · 2012Article
- Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation.Molecular vision · 2012Article
- Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter.International journal of biochemistry and molecular biology · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Although the roles of survivin in control of cancer cell division and apoptosis as well as targeting survivin for cancer therapeutics have been extensively explored and reviewed, the pathophysiological role of survivin in normal human cells/organs has not been deeply investigated or sufficiently reviewed. Studies in the latter area, however, appear to be important for the identification of different mechanisms of regulation and function of survivin in normal versus abnormal cells and tissues (including cancer), which might ultimately provide the basis for novel approaches for disease treatment with low toxicity. This Review is intended to summarize current observations in the literature related to the physiological and/or pathological roles for survivin in various normal human cells or organs. Our view of potential future research directions for survivin pertinent to potential therapeutic applications will also be discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.