ArticleJournal of bacteriology2006
Global transcriptome analysis of Tropheryma whipplei in response to temperature stresses.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
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- Comparative Transcriptome Analysis of Vibrio splendidus JZ6 Reveals the Mechanism of Its Pathogenicity at Low Temperatures.Applied and environmental microbiology · 2016Article
- Evidence for Cleavage of the Metalloprotease Vsm fromFrontiers in microbiology · 2016Article
- Crude oil as a microbial seed bank with unexpected functional potentials.Scientific reports · 2015Article
- Global transcriptional response to heat shock of the legume symbiont Mesorhizobium loti MAFF303099 comprises extensive gene downregulation.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Changing paradigms in Whipple's disease and infection with Tropheryma whipplei.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Review
- Coxiella burnetii transcriptional analysis reveals serendipity clusters of regulation in intracellular bacteria.PloS one · 2010Article
- Gene expression profile of Helicobacter pylori in response to growth temperature variation.Journal of microbiology (Seoul, Korea) · 2009Article
- Genome-wide screen for temperature-regulated genes of the obligate intracellular bacterium, Rickettsia typhi.BMC microbiology · 2008Article
- Comparative genomic analysis of Tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the WiSP proteins.BMC genomics · 2007Article
- Human galectin-1 and galectin-3 promoteGut microbesArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tropheryma whipplei, the agent responsible for Whipple disease, is a poorly known pathogen suspected to have an environmental origin. The availability of the sequence of the 0.92-Mb genome of this organism made a global gene expression analysis in response to thermal stresses feasible, which resulted in unique transcription profiles. A few genes were differentially transcribed after 15 min of exposure at 43 degrees C. The effects observed included up-regulation of the dnaK regulon, which is composed of six genes and is likely to be under control of two HspR-associated inverted repeats (HAIR motifs) found in the 5' region. Putative virulence factors, like the RibC and IspDF proteins, were also overexpressed. While it was not affected much by heat shock, the T. whipplei transcriptome was strongly modified following cold shock at 4 degrees C. For the 149 genes that were differentially transcribed, eight regulons were identified, and one of them was composed of five genes exhibiting similarity with genes encoding ABC transporters. Up-regulation of these genes suggested that there was an increase in nutrient uptake when the bacterium was exposed to cold stress. As observed for other bacterial species, the major classes of differentially transcribed genes encode membrane proteins and enzymes involved in fatty acid biosynthesis, indicating that membrane modifications are critical. Paradoxically, the heat shock proteins GroEL2 and ClpP1 were up-regulated. Altogether, the data show that despite the lack of classical regulation pathways, T. whipplei exhibits an adaptive response to thermal stresses which is consistent with its specific environmental origin and could allow survival under cold conditions.
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