ArticleProceedings of the National Academy of Sciences of the United States of America1991
HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 249 citations in OpenAlex.
- Quantification of DNA Methylation for Diagnosis and Monitoring of Hepatocellular Carcinoma.Journal of the American College of Surgeons · 2026Article
- Molecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols.Leukemia · 2024Article
- TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer.Haematologica · 2023Article
- The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.Cold Spring Harbor perspectives in medicine · 2020Review
- Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia.International journal of hematology · 2019Review
- The genetics and mechanisms of T cell acute lymphoblastic leukaemia.Nature reviews. Cancer · 2016Review
- Article
- The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.Therapeutic advances in hematology · 2013Article
- The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene.Journal of bone marrow research · 2013Article
- The molecular basis of T cell acute lymphoblastic leukemia.The Journal of clinical investigation · 2012Review
- Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL.Nature medicine · 2012Article
- Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Blood reviews · 2011Review
- Transient responses to NOTCH and TLX1/HOX11 inhibition in T-cell acute lymphoblastic leukemia/lymphoma.PloS one · 2011Article
- Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Molecular cancer · 2010Article
- Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless.The EMBO journal · 2010Article
- Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Genes, chromosomes & cancer · 2010Article
- High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology.Nature methods · 2009Article
- TLX1 (HOX11) immortalization of embryonic stem cell-derived and primary murine hematopoietic progenitors.Current protocols in stem cell biology · 2008Article
- PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.The Biochemical journal · 2008Review
- Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A common chromosomal abnormality in childhood T-cell acute leukemia is a translocation, t(10;14) (q24;q11), that together with the variant t(7;10)(q35;q24) is present in up to 7% of this tumor type. The gene adjacent to the 10q24 region is transcriptionally activated after translocation to either TCRD (14q11) or TCRB (7q35). It encodes a homeobox gene closely related to the developmentally regulated homeotic genes of flies and mammals. The coding capacity of this activated gene, designated HOX11, is undisturbed in a T-cell line carrying the translocation t(7;10)(q35;q24). Therefore, the HOX11 homeobox gene seems to be involved in T-cell tumorigenesis.
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