ReviewNeuroRx : the journal of the American Society for Experimental NeuroTherapeutics2006
The application of NMR-based metabonomics in neurological disorders.
Review in NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 91 citations in OpenAlex.
- Metabolic dysregulation in amyotrophic lateral sclerosis: insights fromMetabolic brain disease · 2025Article
- Metabolomic profiling uncovers diagnostic biomarkers and dysregulated pathways in Parkinson's disease.Frontiers in neurology · 2025Article
- NMR-Based Metabolomics of Rat Hippocampus, Serum, and Urine in Two Models of Autism.Molecular neurobiology · 2022Article
- Effects of Methylphenidate on the Dopamine Transporter and Beyond.Current topics in behavioral neurosciences · 2022Article
- Hippocampal Metabolite Profiles in Two Rat Models of Autism: NMR-Based Metabolomics Studies.Molecular neurobiology · 2020Article
- Untargeted Metabolomic Profiling Using UHPLC-QTOF/MS Reveals Metabolic Alterations Associated with Autism.BioMed research international · 2020Article
- Metabolite Profile of Alzheimer's Disease in the Frontal Cortex as Analyzed by HRMASFrontiers in aging neuroscience · 2018Article
- Neuroprotective and Therapeutic Strategies against Parkinson's Disease: Recent Perspectives.International journal of molecular sciences · 2016Review
- The 1H NMR profile of healthy dog cerebrospinal fluid.PloS one · 2013Article
- Metabonomics-based study of clinical urine samples in suboptimal health with different syndromes.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Metabolic phenotyping and systems biology approaches to understanding neurological disorders.F1000prime reports · 2013Article
- Glutamate and GABA in Appetite Regulation.Frontiers in endocrinology · 2013Article
- Metabonomics adds a new dimension to fragile X syndrome.Genome medicine · 2011Article
- A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model.Genome research · 2011Article
- Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism.Molecular systems biology · 2010Article
- Systems parasitology: effects of Fasciola hepatica on the neurochemical profile in the rat brain.Molecular systems biology · 2010Article
- High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues.Nature protocols · 2010Article
- Article
- Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.Molecular psychiatry · 2009Article
- Biomarkers for neuroAIDS: the widening scope of metabolomics.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advances in postgenomic technologies have radically changed the information output from complex biological systems, generating vast amounts of high complexity data that can be interpreted by means of chemometric and bioinformatic methods to achieve disease diagnosis and prognosis. High-resolution nuclear magnetic resonance (NMR) spectroscopy of biofluids such as plasma, cerebrospinal fluid (CSF), and urine can generate robust, interpretable metabolic fingerprints that contain latent information relating to physiological or pathological status. This technology has been successfully applied to both preclinical and clinical studies of neurodegenerative diseases such as Huntington's disease, muscular dystrophy, and cerebellar ataxia. An extension of this technology, (1)H magic-angle-spinning (HRMAS) NMR spectroscopy, can be used to generate metabolic information on small intact tissue samples, providing a metabolic link between metabolic profiling of biofluids and histology. In this review we provide a summary of high-resolution NMR studies in neurodegenerative disease and explore the potential of metabonomics in evaluating disease progression with respect to therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.