ReviewNeuroRx : the journal of the American Society for Experimental NeuroTherapeutics2006
Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer's disease.
Review in NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells.Journal of Alzheimer's disease : JAD · 2023Article
- Unbiased Metabolomic Investigation of Alzheimer's Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism.Journal of proteome research · 2016Article
- Approaches for targeted proteomics and its potential applications in neuroscience.Journal of biosciences · 2015Review
- Separation of biological proteins by liquid chromatography.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2010Article
- Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.Journal of neuroinflammation · 2010Article
- Factors associated with resistance to dementia despite high Alzheimer disease pathology.Neurology · 2009Article
- Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry.Journal of proteome research · 2008Article
- Two-dimensional protein electrophoresis: from molecular pathway discovery to biomarker discovery in neurological disorders.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2006Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Systems biology offers enormous potential to understand the complexity of human brain aging and neurodegenerative diseases. Proteomics has an important role in these investigations because of its unique strengths and because of the potential central pathogenic contribution of pathological protein to several of these diseases. Here we have reviewed the methods and presented some examples of liquid chromatography-electrospray ionization-tandem mass spectrometry-based proteomics, with and without quantification using isotope-coded affinity tags, in the investigation of aging and Alzheimer's disease. As protocols and methods for improved quantitative high-throughput proteomics constantly improve, this approach will likely continue to provide deeper insight into human brain aging and neurodegenerative diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.