ArticleCell metabolism2006
Role of adiponectin in human skeletal muscle bioenergetics.
Article in Cell metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01431677 (Muscle Biopsies in Healthy Volunteers), which is not on this map. Cited by 101 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Muscle Biopsies in Healthy Volunteers: a Pilot Study
Who cites it
101 citing papers in PubMed, 228 citations in OpenAlex.
- Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW.Diabetes care · 2014Trial
- Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial.PloS one · 2013Trial
- Muscle ceramide content is similar after 3 weeks' consumption of fat or carbohydrate diet in a crossover design in patients with type 2 diabetes.European journal of applied physiology · 2012Trial
- Influence of exercise intensity on abdominal fat and adiponectin in elderly adults.Metabolic syndrome and related disorders · 2009Trial
- Trial
- Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight.European journal of applied physiology · 2009Trial
- The effect of moderate alcohol consumption on adiponectin oligomers and muscle oxidative capacity: a human intervention study.Diabetologia · 2007Trial
- Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.PLoS medicine · 2007Trial
- The effect of ascorbic acid supplementation on plasma leptin and adiponectin levels: Systematic review ofCurrent therapeutic research, clinical and experimental · 2026Review
- The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome.Science advances · 2026Article
- Downregulation of microRNA-494 drives mitochondrial biogenesis and function in trained muscle.Experimental physiology · 2026Article
- Myosteatosis: Epidemiological Insights, Functional Decline, and Diagnostic Advances.Current obesity reports · 2025Review
- Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.Cell communication and signaling : CCS · 2025Article
- Adipocyte endothelin B receptor activation inhibits adiponectin production and causes insulin resistance in obese mice.Acta physiologica (Oxford, England) · 2024Article
- Serum Adiponectin Predicts COVID-19 Severity.Biomedicines · 2024Article
- Metformin Inefficiency to Lower Lipids in Vitamin B12 Deficient HepG2 Cells Is Alleviated via Adiponectin-AMPK Axis.Nutrients · 2023Article
- Article
- Adiponectin gene therapy prevents islet loss after transplantation.Journal of cellular and molecular medicine · 2022Article
- Humanin and diabetes mellitus: A review ofWorld journal of diabetes · 2022Review
- Beta-klotho in type 2 diabetes mellitus: From pathophysiology to therapeutic strategies.Reviews in endocrine & metabolic disorders · 2021Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Insulin resistance is associated with impaired skeletal muscle oxidation capacity and reduced mitochondrial number and function. Here, we report that adiponectin signaling regulates mitochondrial bioenergetics in skeletal muscle. Individuals with a family history of type 2 diabetes display skeletal muscle insulin resistance and mitochondrial dysfunction; adiponectin levels strongly correlate with mtDNA content. Knockout of the adiponectin gene in mice is associated with insulin resistance and low mitochondrial content and reduced mitochondrial enzyme activity in skeletal muscle. Adiponectin treatment of human myotubes in primary culture induces mitochondrial biogenesis, palmitate oxidation, and citrate synthase activity, and reduces the production of reactive oxygen species. The inhibition of adiponectin receptor expression by siRNA, or of AMPK by a pharmacological agent, blunts adiponectin induction of mitochondrial function. Our findings define a skeletal muscle pathway by which adiponectin increases mitochondrial number and function and exerts antidiabetic effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.