ArticleVirology journal2006
Evidence of structural genomic region recombination in Hepatitis C virus.
Article in Virology journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Mixed Infections Unravel Novel HCV Inter-Genotypic Recombinant Forms within the Conserved IRES Region.Viruses · 2024Article
- High recombination rate of hepatitis C virus revealed by a green fluorescent protein reconstitution cell system.Virus evolution · 2022Article
- Hepatitis C virus genotype 1 and 2 recombinant genomes and the phylogeographic history of the 2k/1b lineage.Virus evolution · 2019Article
- Evolutionary and Phylogenetic Analysis of the Hepaciviruses and Pegiviruses.Genome biology and evolution · 2015Article
- Characterization of Hepatitis C Virus Recombination in Cameroon by Use of Nonspecific Next-Generation Sequencing.Journal of clinical microbiology · 2015Article
- Hepatitis C virus genetic variability and evolution.World journal of hepatology · 2015Review
- Article
- Cell type-dependent RNA recombination frequency in the Japanese encephalitis virus.BioMed research international · 2014Article
- Article
- Origin and evolution of the unique hepatitis C virus circulating recombinant form 2k/1b.Journal of virology · 2012Article
- Recombination in hepatitis C virus.Viruses · 2011Review
- Near-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis C virus isolates.Advances in virology · 2011Article
- Stability of yellow fever virus under recombinatory pressure as compared with chikungunya virus.PloS one · 2011Article
- Evidence of recombination in Hepatitis C Virus populations infecting a hemophiliac patient.Virology journal · 2009Article
- Evidence for a complex mosaic genome pattern in a full-length hepatitis C virus sequence.Evolutionary bioinformatics online · 2008Article
- Quasispecies and its impact on viral hepatitis.Virus research · 2007Review
- Serendipitous identification of natural intergenotypic recombinants of hepatitis C in Ireland.Virology journal · 2006Article
- Evidence of recombination in quasispecies populations of a Hepatitis C Virus patient undergoing anti-viral therapy.Virology journal · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimHepatitis C virus (HCV) has been the subject of intense research and clinical investigation as its major role in human disease has emerged. Although homologous recombination has been demonstrated in many members of the family Flaviviridae, to which HCV belongs, there have been few studies reporting recombination on natural populations of HCV. Recombination break-points have been identified in non structural proteins of the HCV genome. Given the implications that recombination has for RNA virus evolution, it is clearly important to determine the extent to which recombination plays a role in HCV evolution. In order to gain insight into these matters, we have performed a phylogenetic analysis of 89 full-length HCV strains from all types and sub-types, isolated all over the world, in order to detect possible recombination events.
methodPutative recombinant sequences were identified with the use of SimPlot program. Recombination events were confirmed by bootscaning, using putative recombinant sequence as a query.
resultsTwo crossing over events were identified in the E1/E2 structural region of an intra-typic (1a/1c) recombinant strain.
conclusionOnly one of 89 full-length strains studied resulted to be a recombinant HCV strain, revealing that homologous recombination does not play an extensive roll in HCV evolution. Nevertheless, this mechanism can not be denied as a source for generating genetic diversity in natural populations of HCV, since a new intra-typic recombinant strain was found. Moreover, the recombination break-points were found in the structural region of the HCV genome.
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