ArticleIntensive care medicine2006
Platelet and soluble CD40L in meningococcal sepsis.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- Single-cell transcriptomic and m6A methylation analyses reveal platelet-mediated immune regulatory mechanisms in sepsis.Frontiers in immunology · 2025Article
- Blood Platelets in Infection: The Multiple Roles of the Platelet Signalling Machinery.International journal of molecular sciences · 2023Review
- Systemic inflammatory markers of persistent cerebral edema after aneurysmal subarachnoid hemorrhage.Journal of neuroinflammation · 2022Article
- An Insight into Recent Advances on Platelet Function in Health and Disease.International journal of molecular sciences · 2022Review
- Platelets as Key Factors in Inflammation: Focus on CD40L/CD40.Frontiers in immunology · 2022Review
- Persistently higher serum sCD40L levels are associated with outcome in septic patients.BMC anesthesiology · 2021Observational
- Platelets and infections - complex interactions with bacteria.Frontiers in immunology · 2015Review
- Rac1 regulates platelet shedding of CD40L in abdominal sepsis.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Metalloproteinases regulate CD40L shedding from platelets and pulmonary recruitment of neutrophils in abdominal sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis.Critical care (London, England) · 2011Article
- Microvascular thrombosis and CD40/CD40L signaling.Journal of thrombosis and haemostasis : JTH · 2011Article
- Role of platelet TLR4 expression in pathogensis of septic thrombocytopenia.World journal of emergency medicine · 2011Article
- Soluble CD40L (CD154) is increased in patients with shock.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Protective effect of resin adsorption on septic plasma-induced tubular injury.Critical care (London, England) · 2010Article
- Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9.Intensive care medicine · 2007Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the influence of meningococcal sepsis on levels of platelet derived CD40L and on endothelial CD40 expression. DESIGN AND
settingProspective observational study in two tertiary paediatric intensive care units. PATIENTS AND
participants63 children with meningococcal sepsis and 10 age-matched controls. MEASUREMENTS AND
results(a) sCD40L ELISA of plasma from patients with meningococcal sepsis (n = 49) and age matched controls (n = 10). This demonstrated higher sCD40L levels in patients (median 0.29 ng/ml, IQR 0.2-0.41) than controls (0.09 ng/ml, 0.08-0.12). However, there was no relationship between plasma sCD40L level and platelet count or disease severity. (b) Flow cytometry of fresh blood from patients with meningococcal sepsis (n = 11) and age-matched controls (n = 10) for membrane bound CD40L and CD62P on circulating platelets. This demonstrated low levels of CD40L and CD62P in patients and controls. CD40L+ platelets were 3.5% (3.0-4.8) in patients and 4.9% (3.5-4.3) in controls. CD62P+ platelets were 10.7% (6.4-12.8) in patients and 7.9% (5.9-13.0) in controls. (c) Immunohistochemistry of skin biopsy specimens from six patients, staining for endothelial CD40 expression at sites of microthrombus formation, which demonstrated preserved CD40 expression in vascular endothelium at sites of microthrombus formation.
conclusionsThe elevated sCD40L level in meningococcal sepsis implies release of sCD40L from platelets. However, there was no relationship between plasma sCD40L level and the degree of thrombocytopenia or disease severity. Furthermore, platelet surface bound CD40L was similar in controls and patients. Thus, further investigation is needed to determine whether platelet CD40L contributes to inflammation and thrombosis in MCS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.