ArticleApplied microbiology and biotechnology2006
Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes.
Article in Applied microbiology and biotechnology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Unusual Sesquiterpenes fromJournal of natural products · 2024Article
- Unveiling metabolo-genomic insights of potent antitumoral and antibiotic activity inFrontiers in microbiology · 2024Article
- Targeted genome mining for microbial antitumor agents acting through DNA intercalation.Synthetic and systems biotechnology · 2023Article
- Mycothiol Peroxidase Activity as a Part of the Self-Resistance Mechanisms against the Antitumor Antibiotic Cosmomycin D.Microbiology spectrum · 2022Article
- Great diversity of KSFEMS microbes · 2022Article
- Omics Technologies to Understand Activation of a Biosynthetic Gene Cluster in Micromonospora sp. WMMB235: Deciphering Keyicin Biosynthesis.ACS chemical biology · 2019Article
- New Alpiniamides FromFrontiers in microbiology · 2018Article
- Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin.ACS chemical biology · 2017Article
- AFEAP cloning: a precise and efficient method for large DNA sequence assembly.BMC biotechnology · 2017Article
- Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.Cell chemical biology · 2017Article
- PCR-Independent Method of Transformation-Associated Recombination Reveals the Cosmomycin Biosynthetic Gene Cluster in an Ocean Streptomycete.Journal of natural products · 2017Article
- Article
- Genome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D.Genome announcements · 2014Article
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11 authors.
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Abstract
Glycosylation pattern in cosmomycins is a distinctive feature among anthracyclines. These antitumor compounds possess two trisaccharide chains attached at C-7 and C-10, each of them with structural variability, mainly at the distal deoxysugar moieties. We have characterized a 14-kb chromosomal region from Streptomyces olindensis containing 13 genes involved in cosmomycin biosynthesis. Two of the genes, cosG and cosK, coding for glycosyltransferase were inactivated with the generation of five new derivatives. Structural elucidation of these compounds showed altered glycosylation patterns indicating the capability of both glycosyltransferases of transferring deoxysugars to both sides of the aglycone and the flexibility of CosK with respect to the deoxysugar donor. A model is proposed for the glycosylation steps during cosmomycins biosynthesis.
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