ArticleThe EMBO journal2006
Combinatorial control of Arabidopsis proline dehydrogenase transcription by specific heterodimerisation of bZIP transcription factors.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100 citing papers in PubMed, 245 citations in OpenAlex.
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- Genome-wide analysis of flax bZIP genes using a T2T genome reveals abiotic stress roles.iScience · 2026Article
- Overexpression of the Transcription FactorInternational journal of molecular sciences · 2025Article
- The Proline Dehydrogenase GeneInternational journal of molecular sciences · 2025Article
- Genome-Wide Analysis of bZIP Transcription Factors and Expression Patterns in Response to Salt and Drought Stress inInternational journal of molecular sciences · 2025Article
- Proline and ROS: A Unified Mechanism in Plant Development and Stress Response?Plants (Basel, Switzerland) · 2024Review
- In silico analysis identified bZIP transcription factors genes responsive to abiotic stress in Alfalfa (Medicago sativa L.).BMC genomics · 2024Article
- Genome-Wide Analysis of C/S1-bZIP Subfamilies inInternational journal of molecular sciences · 2024Article
- PfbZIP85 Transcription Factor Mediates ω-3 Fatty Acid-Enriched Oil Biosynthesis by Down-RegulatingInternational journal of molecular sciences · 2024Article
- Mechanically induced localisation of SECONDARY WALL INTERACTING bZIP is associated with thigmomorphogenic and secondary cell wall gene expression.Quantitative plant biology · 2024Article
- Systematic Identification and Functional Analysis of theInternational journal of molecular sciences · 2023Article
- Double DAP-seq uncovered synergistic DNA binding of interacting bZIP transcription factors.Nature communications · 2023Article
- Divergence of functions and expression patterns of soybean bZIP transcription factors.Frontiers in plant science · 2023Review
- Identification and Characterization of Physiological Pairing of E2 Ubiquitin-Conjugating Enzymes and E3 Ubiquitin Ligases.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Genome-wide characterization of the TALE homeodomain family and the KNOX-BLH interaction network in tomato.Plant molecular biology · 2022Article
- The DnaJ-like Zinc Finger Protein ORANGE Promotes Proline Biosynthesis in Drought-StressedInternational journal of molecular sciences · 2022Article
- MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression.PLoS genetics · 2022Article
- Association mapping uncovers maizeFrontiers in plant science · 2022Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proline metabolism has been implicated in plant responses to abiotic stresses. The Arabidopsis thaliana proline dehydrogenase (ProDH) is catalysing the first step in proline degradation. Transcriptional activation of ProDH by hypo-osmolarity is mediated by an ACTCAT cis element, a typical binding site of basic leucine zipper (bZIP) transcription factors. In this study, we demonstrate by gain-of-function and loss-of-function approaches, as well as chromatin immunoprecipitation (ChIP), that ProDH is a direct target gene of the group-S bZIP factor AtbZIP53. Dimerisation studies making use of yeast and Arabidopsis protoplast-based two-hybrid systems, as well as bimolecular fluorescence complementation (BiFC) reveal that AtbZIP53 does not preferentially form dimers with group-S bZIPs but strongly interacts with members of group-C. In particular, a synergistic interplay of AtbZIP53 and group-C AtbZIP10 was demonstrated by colocalisation studies, strong enhancement of ACTCAT-mediated transcription as well as complementation studies in atbzip53 atbzip10 T-DNA insertion lines. Heterodimer mediated activation of transcription has been found to operate independent of the DNA-binding properties and is described as a crucial mechanism to modulate transcription factor activity and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.