ArticleRNA (New York, N.Y.)2006
Structural study of elements of Tetrahymena telomerase RNA stem-loop IV domain important for function.
Article in RNA (New York, N.Y.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Critical Assessment of RNA and DNA Structure Predictions via Artificial Intelligence: The Imitation Game.Journal of chemical information and modeling · 2025Article
- Structure of LARP7 Protein p65-telomerase RNA Complex in Telomerase Revealed by Cryo-EM and NMR.Journal of molecular biology · 2023Article
- Structural Biology of Telomerase.Cold Spring Harbor perspectives in biology · 2019Review
- Single-Molecule Analysis of Reverse Transcriptase Enzymes.Cold Spring Harbor perspectives in biology · 2019Review
- De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.Nature methods · 2018Article
- Progress in Human and Tetrahymena Telomerase Structure Determination.Annual review of biophysics · 2017Review
- Structure and folding of the Tetrahymena telomerase RNA pseudoknot.Nucleic acids research · 2017Article
- Evolutionary perspectives of telomerase RNA structure and function.RNA biology · 2016Review
- Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPE.RNA (New York, N.Y.) · 2015Article
- Structural basis for protein-RNA recognition in telomerase.Nature structural & molecular biology · 2014Article
- Progress in structural studies of telomerase.Current opinion in structural biology · 2014Review
- Article
- xRRM: a new class of RRM found in the telomerase La family protein p65.RNA biology · 2013Review
- New models of Tetrahymena telomerase RNA from experimentally derived constraints and modeling.Journal of the American Chemical Society · 2012Article
- Biogenesis of telomerase ribonucleoproteins.RNA (New York, N.Y.) · 2012Review
- Stiffened yeast telomerase RNA supports RNP function in vitro and in vivo.RNA (New York, N.Y.) · 2012Article
- Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65.Molecular cell · 2012Article
- Telomere lengthening and other functions of telomerase.Acta naturae · 2012Article
- The C-terminal domain of Tetrahymena thermophila telomerase holoenzyme protein p65 induces multiple structural changes in telomerase RNA.RNA (New York, N.Y.) · 2012Article
- Single-molecule analysis of telomerase structure and function.Current opinion in chemical biology · 2011Review
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Authors and funding
6 authors.
Funding
Abstract
Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem-loop IV domain, which is involved in both catalysis and RNP assembly, and includes binding sites for both the holoenzyme assembly protein p65 and telomerase reverse transcriptase (TERT). Stem-loop IV contains two regions with high evolutionary sequence conservation: a central GA bulge between helices, and a terminal loop. We solved the solution structure of loop IV and modeled the structure of the helical region containing the GA bulge, using NMR and residual dipolar couplings. The central GA bulge with flanking C-G base pairs induces a approximately 50 degrees semi-rigid bend in the helix. Loop IV is highly structured, and contains a conserved C-U base pair at the top of the helical stem. Analysis of new and previous biochemical data in light of the structure provides a rationale for some of the sequence conservation in this region of TER. The results suggest that during holoenzyme assembly the protein p65 recognizes a bend in stem IV, and this binding to central stem IV helps to position the structured loop IV for interaction with TERT and other region(s) of TER.
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