Evidence map›Paper›PMID 16809409›Full record

ArticleThorax2006

Statin treatment and reduced risk of pneumonia in patients with diabetes.

E M W van de Garde, E Hak, P C Souverein, A W Hoes, J M M van den Bosch, H G M Leufkens

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 5 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
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  6. Trial
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  9. The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2012 · on this map
    Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Article
  15. Diabetic lung disease: fact or fiction?Reviews in endocrine & metabolic disorders · 2019
    Review
  16. Article
  17. Article
  18. The Use of Statins and Risk of Community-Acquired Pneumonia.Current infectious disease reports · 2017
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

E M W van de GardeUtrecht Institute for Pharmaceutical Sciences (UIPS), Department of Pharmacoepidemiology and Pharmacotherapy, Sorbonnelaan 16, 3583 CA Utrecht, The Netherlands. e.m.w.vandegarde@pharm.uu.nl
E Hak
P C Souverein
A W Hoes
J M M van den Bosch
H G M Leufkens
Pharmo Institute · NLUniversity Medical Center Utrecht · NLSt. Antonius Ziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent prognostic studies have shown that previous treatment with statins is associated with a better outcome in patients admitted to hospital with pneumonia. Because of an increased risk of pneumonia in patients with diabetes, we assessed the effects of statin use on the occurrence of pneumonia in adult diabetic patients.

methodsAll patients with a diagnosis of diabetes (types 1 and 2) enlisted in the UK General Practice Research Database between 1 June 1987 and 21 January 2001 were included. A case-control study was performed with cases defined as patients with a first recorded diagnosis of pneumonia. For each case up to four controls were matched by age, sex, practice, and index date. Patients were classified as current users when the index date was between the start and end date of statin treatment. Conditional multiple logistic regression analysis was used to estimate the strength of the association between statin treatment and the occurrence of pneumonia.

resultsStatins were used in 1.1% of 4719 cases and in 2.1% of 15 322 matched controls (crude odds ratio (OR) 0.51, 95% CI 0.37 to 0.68). After adjusting for potential confounders, treatment with statins was associated with a significant reduction in the risk of pneumonia (adjusted OR 0.49, 95% CI 0.35 to 0.69). The association was consistent among relevant subgroups (cardiovascular diseases, pulmonary diseases) and independent of the use of other prescription drugs.

conclusionsThe use of statins is associated with a considerable reduction in the risk of pneumonia in diabetic patients. In addition to lowering the risk of cardiovascular disease, statins may be useful in preventing respiratory infections.

Indexed as

AdolescentAdultAgedAged, 80 and overCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPneumoniaRegression AnalysisRetrospective StudiesRisk FactorsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID16809409
PMCPMC2121156
OpenAlexW2144170194

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.